Tryptase inhibitor

spinqualitylabelsall models Structure of leech tryptase inhibitor (magenta) complex with trypsin (cyan) and Ca+2 ion (green) (PDB entry 1ldt) Show:Asymmetric Unit Biological Assembly Drag the structure with the mouse to rotate   Export Animated Image   Print3D Tryptase inhibitors (TI) are protein inhibitors of tryptase belonging to the group of Kazal-type inhibitors and exhibiting a distinctive disulfide pattern. Relevance TI are used as anti-inflammatory agents in treating asthma and other airway inflammation diseases. Tryptase was found in elevated levels in various kinds of allergic inflammations. Tryptase inhibitor/trypsin interactions (PDB entry 1ldt).

3D structures of tryptase inhibitor

Updated on 27-September-2018

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• Leech-derived tryptase inhibitor
  • 1ldt – MlTI + trypsin – Medicinal leech
    
  • 1an1 - MlTI (mutant) + trypsin
    
  • 2kmo, 2kmp, 2kmq, 2kmr – MlTI - NMR
• Tick-derived tryptase inhibitor
  • 2uux – tTI residues 44-96 – tick
    
  • 2uuy - tTI + trypsin
    
  • 2lfk, 2lfl – tTI - NMR

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