Virus protease

spinqualitylabelsall models HIV-1 protease dimer complex with tert-butylcarbonate (PDB entry 1odw) Show:Asymmetric Unit Biological Assembly Drag the structure with the mouse to rotate   Export Animated Image   Print3D Virus proteases include HIV protease, XMRV protease, retropepsin. HIV Protease (HIV-PR) and xenotropic murine leukemia virus protease (XMRV-PR) cleave polyproteins to produce the mature proteins of the virus. Both are aspartyl proteases. The inhibition of HIV-PR results in an uninfectious HIV virion. HIV-1 is found globally while HIV-2, which has lower virulence, is found in West Africa. HIV-1 protease dimer complex with inhibitor tert-butylcarbonate . Inhibitor BMS-182193 binding site. See also Immunodeficiency virus protease Human Immunodeficiency Virus HIV-1 protease HIV Protease Inhibitor Pharmacokinetics HIV Protease Inhibitor Resistance Profile HIV Protease Resistance Molecular Playground/Dengue Virus Protease Viability of a drug-resistant HIV-1 protease mutant Molecular Playground/Dengue Virus Protease

3D Structures of Virus proteases

Updated on 05-October-2018

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• HIV-1 protease . See Immunodeficiency virus protease
• HIV-2 protease See Human Immunodeficiency Virus
• Feline Immunodeficiency virus protease See HIV-1 protease

• Simian Immunodeficiency virus protease See HIV Protease Inhibitor Pharmacokinetics
• Xenotropic murine leukemia virus protease
  • HIV Protease Inhibitor Resistance Profile – XMRV-PR P14
    
  • HIV Protease Resistance – XMRV-PR RNase H domain (mutant)
    
  • Molecular Playground/Dengue Virus Protease – XMRV-PR residues 533-657 + inhibitor
    
  • Viability of a drug-resistant HIV-1 protease mutant – XMRV-PR residues 533-657 + pepstatin
    
  • Molecular Playground/Dengue Virus Protease – XMRV-PR residues 533-657 + amprenavir
    
• Human T-cell leukemia virus protease
  • 2b7f – HTLV-PV + peptide
    
  • 3lin, 3liq, 3lit, 3liv, 3lix, 3liy, 4ydg, 4ydf – HTLV-PV (mutant) + inhibitor
    
• Rous sarcoma virus protease
  • 2rsp – RSVP - Rous sarcoma virus
    
  • 1bai – RSVP + polypeptide inhibitor
• Human Cytomegalovirus protease
  • 1wpo – CMVP - human herpes virus 5
    
  • 1cmv, 1lay, 1jq6, 1id4, 1iec, 1ied, 1ief, 1ieg – CMVP (mutant)
    
  • 2wpo, 1jq7 - CMVP (mutant) + inhibitor
    
  • 1njt, 1nju, 1nkk, 1nkm - CMVP (mutant) + peptide inhibitor
    
• Varicella-Zoster virus protease
  • 1vzv - VZVP (mutant) – human herpes virus
• Equine infectious anemia virus protease
  • 2fmb, 1fmb – EIAVP (mutant) + inhibitor
• Hepatitis A virus protease
  • 2h9h, 2hal – HAVP residues 1520-1731 (mutant) + polypeptide inhibitor
• Hepatitis C virus protease
  • 2o8m – HCVP (mutant)
    
  • 2a4g, 2gvf, 2f9u, 2f9v – HCVP + peptide inhibitor
    
• Orf 17
  • 3njq – hOrf 17 - human herpes virus 8
• Dengue virus protease
  • 3u1i – DvNs2b + peptide – Dengue virus
    
  • 3u1j – DvNs2b + BPTI
    
  • 2fom - DvNs2b/DvNs3
    
  • 4m9f, 4m9i, 4m9k, 4m9m, 3lkw - DvNs2b/DvNs3 (mutant)
    
  • 4m9t - DvNs2b/DvNs3 (mutant) + inhibitor
    
  • 2jlq – DvNs3 residues 1646-2092
    
  • 2jlv – DvNs3 residues 1646-2092 + AMPPNP + RNA
    
  • 2jlr – DvNs3 residues 1646-2092 + AMPPNP
    
  • 2jls – DvNs3 residues 1646-2092 + ADP
    
  • 2jlx, 2jly, 2jlz – DvNs3 residues 1646-2092 + ADP + RNA
    
  • 2jlu, 2jlw – DvNs3 residues 1646-2092 + RNA
    
  • 2vbc, 2whx, 2wzq – DvNs3 residues 1475-2092 + peptide inhibitor
    
  • 2m9p, 2m9q – DvNs3 residues 1475-1648 + peptide inhibitor - NMR
    
• Herpes simplex virus protease
  • 1at3 – HSV II – human herpesvirus 2
• Foot-and-Mouth Disease virus protease
  • 2bhg – FMDV – Foot-and-mouth disease virus
• Infectious Bronchitis virus protease
  • 2q6d – IBV – infectious bronchitis virus
    
  • 2q6f – IBV + inhibitor
• Yellowtail ascites virus protease
  • 4izj, 4izk – YAV Vp4 (mutant) – yellowtail ascites virus
• Pseudorabies virus protease
  • 4cx8 – YAV – pseudorabies virus
    

Proteopedia Page Contributors and Editors (what is this?)

Michal Harel, Alexander Berchansky, Jaime Prilusky, Joel L. Sussman