Virus protease

spinqualitylabelsall models Structure of human rhinovirus 3C protease complex with inhibitor (PDB entry 1cqq) Show:Asymmetric Unit Biological Assembly Drag the structure with the mouse to rotate   Export Animated Image   Print3D Function 3C protease (3CP) is a virus cysteine protease which has essential role in viral replication. 3CP cleaves the precursor viral polyprotein to produce functional proteins and enzymes. For more details on Foot and Mouth Disease virus 3C protease see FMDV 3C. Disease 3CP is an attractive target for therapeutic agents for treatment of diseases caused by the common cold virus. Coxsakievirus causes the human diseases myocarditis and pericarditis. Structural highlights 3CP - a Cys protease fold is similar to that of trypsin-like serine proteases. The active site triad contains Cys147, His40 and Glu71 (PDB entry 1cqq). Whole binding site. See also Immunodeficiency virus protease Human Immunodeficiency Virus HIV-1 protease HIV Protease Inhibitor Pharmacokinetics HIV Protease Inhibitor Resistance Profile HIV Protease Resistance Molecular Playground/Dengue Virus Protease Viability of a drug-resistant HIV-1 protease mutant Molecular Playground/Dengue Virus Protease

3D Structures of Virus proteases

Updated on 08-October-2018

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• HIV-1 protease . See FMDV 3C
• HIV-2 protease See 1cqq
• Feline Immunodeficiency virus protease See Immunodeficiency virus protease

• Simian Immunodeficiency virus protease See Human Immunodeficiency Virus
• Xenotropic murine leukemia virus protease
  • HIV-1 protease – XMRV-PR P14
    
  • HIV Protease Inhibitor Pharmacokinetics – XMRV-PR RNase H domain (mutant)
    
  • HIV Protease Inhibitor Resistance Profile – XMRV-PR residues 533-657 + inhibitor
    
  • HIV Protease Resistance – XMRV-PR residues 533-657 + pepstatin
    
  • Molecular Playground/Dengue Virus Protease – XMRV-PR residues 533-657 + amprenavir
    
• Human T-cell leukemia virus protease
  • Viability of a drug-resistant HIV-1 protease mutant – HTLV-PV + peptide
    
  • Molecular Playground/Dengue Virus Protease, 3liq, 3lit, 3liv, 3lix, 3liy, 4ydg, 4ydf – HTLV-PV (mutant) + inhibitor
    
• Rous sarcoma virus protease
  • 2rsp – RSVP - Rous sarcoma virus
    
  • 1bai – RSVP + polypeptide inhibitor
• Human Cytomegalovirus protease
  • 1wpo – CMVP - human herpes virus 5
    
  • 1cmv, 1lay, 1jq6, 1id4, 1iec, 1ied, 1ief, 1ieg – CMVP (mutant)
    
  • 2wpo, 1jq7 - CMVP (mutant) + inhibitor
    
  • 1njt, 1nju, 1nkk, 1nkm - CMVP (mutant) + peptide inhibitor
    
• Varicella-Zoster virus protease
  • 1vzv - VZVP (mutant) – human herpes virus
• Equine infectious anemia virus protease
  • 2fmb, 1fmb – EIAVP (mutant) + inhibitor
• Hepatitis A virus protease
  • 2h9h, 2hal – HAVP residues 1520-1731 (mutant) + polypeptide inhibitor
• Hepatitis C virus protease
  • 2o8m – HCVP (mutant)
    
  • 2a4g, 2gvf, 2f9u, 2f9v – HCVP + peptide inhibitor
    
• Orf 17
  • 3njq – hOrf 17 - human herpes virus 8
• Dengue virus protease
  • 3u1i – DvNs2b + peptide – Dengue virus
    
  • 3u1j – DvNs2b + BPTI
    
  • 2fom - DvNs2b/DvNs3
    
  • 4m9f, 4m9i, 4m9k, 4m9m, 3lkw - DvNs2b/DvNs3 (mutant)
    
  • 4m9t - DvNs2b/DvNs3 (mutant) + inhibitor
    
  • 2jlq – DvNs3 residues 1646-2092
    
  • 2jlv – DvNs3 residues 1646-2092 + AMPPNP + RNA
    
  • 2jlr – DvNs3 residues 1646-2092 + AMPPNP
    
  • 2jls – DvNs3 residues 1646-2092 + ADP
    
  • 2jlx, 2jly, 2jlz – DvNs3 residues 1646-2092 + ADP + RNA
    
  • 2jlu, 2jlw – DvNs3 residues 1646-2092 + RNA
    
  • 2vbc, 2whx, 2wzq – DvNs3 residues 1475-2092 + peptide inhibitor
    
  • 2m9p, 2m9q – DvNs3 residues 1475-1648 + peptide inhibitor - NMR
    
• Herpes simplex virus protease
  • 1at3 – HSV II – human herpesvirus 2
• Foot-and-Mouth Disease virus protease
  • 2bhg – FMDV residues 1650-1857 (mutant) – Foot-and-mouth disease virus
• Infectious Bronchitis virus protease
  • 2q6d – IBV – infectious bronchitis virus
    
  • 2q6f – IBV + inhibitor
• Yellowtail ascites virus protease
  • 4izj, 4izk – YAV Vp4 (mutant) – yellowtail ascites virus
• Pseudorabies virus protease
  • 4cx8 – YAV – pseudorabies virus
    

Proteopedia Page Contributors and Editors (what is this?)

Michal Harel, Alexander Berchansky, Jaime Prilusky, Joel L. Sussman