3o9o | pdb_00003o9o

Crystal Structure of GBS1074, an Esat-6 homologue from Group B Streptococcus

spinqualitylabelsall models 3o9o, resolution 2.00Å Show:Asymmetric Unit Biological Assembly Drag the structure with the mouse to rotate   Export Animated Image   Print3D Structural highlights 3o9o is a 2 chain structure with sequence from Stra3. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance. Gene: gbs1074 (STRA3) Resources: FirstGlance, OCA, PDBe, RCSB, PDBsum, ProSAT Publication Abstract from PubMed ESAT-6 is a well characterized secreted protein from Mycobacterium tuberculosis and represents the archetype of the WXG100 family of proteins. Genes encoding ESAT-6 homologues have been identified in the genome of the human pathogen Streptococcus agalactiae; one of these genes, esxA, has been cloned and the recombinant protein has been crystallized. In contrast to M. tuberculosis ESAT-6, the crystal structure of GBS1074 reveals a homodimeric structure similar to homologous structures from Staphylococcus aureus and Helicobacter pylori. Intriguingly, GBS1074 forms elongated fibre-like assemblies in the crystal structure. The homodimeric GBS1074 from Streptococcus agalactiae.,Shukla A, Pallen M, Anthony M, White SA Acta Crystallogr Sect F Struct Biol Cryst Commun. 2010 Nov 1;66(Pt, 11):1421-5. Epub 2010 Oct 27. PMID:21045286 From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.

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