Polycomb proteins

spinqualitylabelsall models Caption for this structure Show:Asymmetric Unit Biological Assembly Drag the structure with the mouse to rotate   Export Animated Image   Print3D Function Polycomb group (PcG) proteins are determinants of gene silencing and epigenetic memory in higher eukaryotes. The PcG system consists of multimeric repressive protein complexes containing chromatin modifying activities which regulate transcription by modulating chromatin structures. The PcG proteins regulate pathways in cell differentiation, tissue regeneration and cancer cell growth.

3D structures of D-aminoacylase

Updated on 29-October-2018

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• Polycomb BMI1
  • 5fr6 - hPcG - human
    
  • 3rpg - hPcG + RING1B + Ubch5C
    
  • 4r8p - hPcG + RING1B + Ubch5C + histones + DNA
    
• Polycomb EED
  • 5wf7, 5bjs, 5vk3 - CtPcG + EZH2/PcG SUZ12 - Chaetomium thermophilum
    
  • 5wfd - CtPcG + zinc finger containing protein + inhibitor
    
  • 5wfc - CtPcG (mutant) + EZH2/PcG SUZ12 + histone peptide + inhibitor
    
  • 5tqr - CtPcGCP + EZH2/PCP SUZ12 + SAM
    
  • 3jzn - hPcG
    
  • 5wg6 - hPcG + EZH2
    
  • 5ij7, 5ij8, 4w2r, 6b3w - hPcG + EZH2 + PcG SUZ12 + inhibitor
    
  • 5ij8 - hPcG + EZH2 + PcG SUZ12 + inhibitor
    
  • 5ls6 - hPcG + EZH2 + PcG SUZ12 + Jarid2 K116me3
    
  • 5hyn - hPcG + EZH2 + PcG SUZ12 + Jarid2 K116me3 + histone peptide
    
  • 6c23, 6c24 - hPcG + EZH2 + PcG SUZ12 + Jarid2 substrate + Jumonji + SUZ12 + RBBP4 - Cryo EM
    
  • 4x3e - hPcG + Jarid2 peptide
    
  • 3jpx, 3iiw, 3iiy, 3ij0, 3ij1, 3jzg, 3jzh, 3k26,5fr6 - hPcG
    
  • 5u69, 5u6d, 5u8a, 5k0m, 5h13, 5u5h, 5u5k, 5u8f - hPcG + inhibitor
    
  • 3ijc - hPcG (mutant) + inhibitor
    
  • 5wp3 - hPcG + EB22
    
  • 5ttw - hPcG + UNC4859
    
  • 5h14, 5h15, 5h17, 5h19, 5u5t, 5u62, 5h25, 5gsa, 5h24, 5wuk - hPcG + EZH2 + inhibitor
    
  • 1pdq, 1pfb - DmPcG chromodomain + histone peptide - Drosophila melanogaster
    
• Polycomb SUZ12
  • 5wak - hPcG + RBBP4
    
  • 5wai - hPcG + RBBP4 + Jarid2 + AEPB2
    
  • 2yb8 - DmPcG + CAF1
    
• Polycomb SCMH1
  • 2p0k - hPcG
    
• Polycomb SFMBT
  • 4c5e, 4c5g, 4c5h - DmPcG + PcG PHO
    
  • 5j8y - DmPcG + PcG SCM
    
  • 3h6z - DmPcG + histone peptide
    
• Polycomb PCL
  • 2xk0 - DmPcG tudor domain - NMR
    
  • 5oqd - DmPcG Phd2 and winged-helix domain
    
• Polycomb SCM
  • 2r57 - DmPcG (mutant)
    
  • 2r58, 2r5a - DmPcG (mutant) + methyl-lysine
    
  • 2r5m - DmPcG (mutant) + peptide
    

Proteopedia Page Contributors and Editors (what is this?)

Michal Harel, Jaime Prilusky