Polycomb proteins

spinqualitylabelsall models Human polycomb complex protein BMI-1 (olive and dark red) complex with histones (grey, green, yellow, pink, magenta, cyan, gold, red), RING1B/Ubch5C (aqua and orchid)and DNA (blue and gold) PDB code 4r8p Show:Asymmetric Unit Biological Assembly Drag the structure with the mouse to rotate   Export Animated Image   Print3D Function Polycomb group (PcG) proteins are determinants of gene silencing and epigenetic memory in higher eukaryotes. The PcG system consists of multimeric repressive protein complexes containing chromatin modifying activities which regulate transcription by modulating chromatin structures. The PcG proteins regulate pathways in cell differentiation, tissue regeneration and cancer cell growth. Disease Misregulation of PcG protein levels often lead to either a block or unscheduled activation of developmental pathways. the consequences of this misregulation have been linked to the establishment of cancer stem cells which can produce tumors. Cancer stem cells are believed to persist within tumors and to elicit relapse and metastasis

3D structures of polycomb proteins

Updated on 31-October-2018

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• Polycomb BMI1
  • 5fr6 - hPcG - human
    
  • 3rpg - hPcG + RING1B + Ubch5C
    
  • 4r8p - hPcG + RING1B + Ubch5C + histones + DNA
    
• Polycomb EED
  • 5wf7, 5bjs, 5vk3 - CtPcG + EZH2/PcG SUZ12 - Chaetomium thermophilum
    
  • 5wfd - CtPcG + zinc finger containing protein + inhibitor
    
  • 5wfc - CtPcG (mutant) + EZH2/PcG SUZ12 + histone peptide + inhibitor
    
  • 5tqr - CtPcGCP + EZH2/PCP SUZ12 + SAM
    
  • 3jzn - hPcG
    
  • 5wg6 - hPcG + EZH2
    
  • 5ij7, 5ij8, 4w2r, 6b3w - hPcG + EZH2 + PcG SUZ12 + inhibitor
    
  • 5ij8 - hPcG + EZH2 + PcG SUZ12 + inhibitor
    
  • 5ls6 - hPcG + EZH2 + PcG SUZ12 + Jarid2 K116me3
    
  • 5hyn - hPcG + EZH2 + PcG SUZ12 + Jarid2 K116me3 + histone peptide
    
  • 6c23, 6c24 - hPcG + EZH2 + PcG SUZ12 + Jarid2 substrate + Jumonji + SUZ12 + RBBP4 - Cryo EM
    
  • 4x3e - hPcG + Jarid2 peptide
    
  • 3jpx, 3iiw, 3iiy, 3ij0, 3ij1, 3jzg, 3jzh, 3k26,5fr6 - hPcG
    
  • 5u69, 5u6d, 5u8a, 5k0m, 5h13, 5u5h, 5u5k, 5u8f - hPcG + inhibitor
    
  • 3ijc - hPcG (mutant) + inhibitor
    
  • 5wp3 - hPcG + EB22
    
  • 5ttw - hPcG + UNC4859
    
  • 5h14, 5h15, 5h17, 5h19, 5u5t, 5u62, 5h25, 5gsa, 5h24, 5wuk - hPcG + EZH2 + inhibitor
    
  • 1pdq, 1pfb - DmPcG chromodomain + histone peptide - Drosophila melanogaster
    
• Polycomb SUZ12
  • 5wak - hPcG + RBBP4
    
  • 5wai - hPcG + RBBP4 + Jarid2 + AEPB2
    
  • 2yb8 - DmPcG + CAF1
    
• Polycomb SCMH1
  • 2p0k - hPcG
    
• Polycomb SFMBT
  • 4c5e, 4c5g, 4c5h - DmPcG + PcG PHO
    
  • 5j8y - DmPcG + PcG SCM
    
  • 3h6z - DmPcG + histone peptide
    
• Polycomb PCL
  • 2xk0 - DmPcG tudor domain - NMR
    
  • 5oqd - DmPcG Phd2 and winged-helix domain
    
• Polycomb SCM
  • 2r57 - DmPcG (mutant)
    
  • 2r58, 2r5a - DmPcG (mutant) + methyl-lysine
    
  • 2r5m - DmPcG (mutant) + peptide
    

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Michal Harel, Jaime Prilusky