6cmv | pdb_00006cmv

Crystal structure of Archaeal Biofilm Regulator (AbfR2) from Sulfolobus acidocaldarius

spinqualitylabelsall models 6cmv, resolution 2.45Å Show:Asymmetric Unit Biological Assembly Drag the structure with the mouse to rotate   Export Animated Image   Print3D Structural highlights 6cmv is a 6 chain structure. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance. Ligands: GOL, MPD NonStd Res: MSE Resources: FirstGlance, OCA, PDBe, RCSB, PDBsum, ProSAT Publication Abstract from PubMed The small winged helix-turn-helix (wHTH) proteins of the Lrs14 family are major transcriptional regulators and act as archaeal biofilm regulators (AbfRs) in the crenarchaeote Sulfolobus acidocaldarius. Here, the first crystal structure of an AbfR ortholog, AbfR2, the deletion of which is known to impair biofilm formation, is presented. Like most other wHTH orthologs, AbfR2 is dimeric in solution as well as in its 2.45 A resolution crystal structure. Given the presence of three independent AbfR2 dimers in the asymmetric unit, the crystal structure shows a considerable degree of conformational variation within the dimer, the antiparallel orientations of which are stabilized by coiled-coil interaction between H4 helices. Conserved anchor interactions between helices H0 and H4 of AbfR2 further contribute to dimer stabilization. The combined structural and bioinformatic analysis reveals cluster-specific structural differences between different members of the Lrs14 protein family. Crystal structure of an Lrs14-like archaeal biofilm regulator from Sulfolobus acidocaldarius.,Vogt MS, Volpel SL, Albers SV, Essen LO, Banerjee A Acta Crystallogr D Struct Biol. 2018 Nov 1;74(Pt 11):1105-1114. doi:, 10.1107/S2059798318014146. Epub 2018 Oct 29. PMID:30387769 From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.

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