3dez | pdb_00003dez

Crystal structure of Orotate phosphoribosyltransferase from Streptococcus mutans

spinqualitylabelsall models 3dez, resolution 2.40Å Show:Asymmetric Unit Biological Assembly Drag the structure with the mouse to rotate   Export Animated Image   Print3D Structural highlights 3dez is a 2 chain structure with sequence from Atcc 25175. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance. Ligands: SO4 Gene: pyrE (ATCC 25175) Activity: Orotate phosphoribosyltransferase, with EC number 2.4.2.10 Resources: FirstGlance, OCA, PDBe, RCSB, PDBsum, ProSAT Function [PYRE_STRMU] Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP). Evolutionary Conservation Check, as determined by ConSurfDB. You may read the explanation of the method and the full data available from ConSurf. Publication Abstract from PubMed Orotate phosphoribosyltransferase (OPRTase) catalyzes the OMP-forming step in de novo pyrimidine-nucleotide biosynthesis. Here, the crystal structure of OPRTase from the caries pathogen Streptococcus mutans is reported at 2.4 A resolution. S. mutans OPRTase forms a symmetric dimer and each monomer binds two sulfates at the active sites. The structural symmetry of the sulfate-binding sites and the missing loops in this structure are consistent with a symmetric catalysis mechanism. Structure of orotate phosphoribosyltransferase from the caries pathogen Streptococcus mutans.,Liu CP, Xu R, Gao ZQ, Xu JH, Hou HF, Li LQ, She Z, Li LF, Su XD, Liu P, Dong YH Acta Crystallogr Sect F Struct Biol Cryst Commun. 2010 May 1;66(Pt, 5):498-502. Epub 2010 Apr 29. PMID:20445243 From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine. See Also Phosphoribosyltransferase

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