6bol | pdb_00006bol

Crystal structure of mutant 2-methylcitrate synthase mcsAG419A from Aspergillus fumigatus.

spinqualitylabelsall models 6bol, resolution 2.20Å Show:Asymmetric Unit Biological Assembly Drag the structure with the mouse to rotate   Export Animated Image   Print3D Structural highlights 6bol is a 2 chain structure with sequence from Aspfc. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance. Ligands: CL, OAA, PO4 Gene: mcsA, AFUB_094700 (ASPFC) Resources: FirstGlance, OCA, PDBe, RCSB, PDBsum, ProSAT Function [PRPC_ASPFC] Component of the methylcitrate cycle that catalyzes the synthesis of (2S,3S)-2-methylcitrate from propionyl-CoA and oxaloacetate. Plays an important role in detoxification of propionyl-CoA, an inhibitor of both primary and secondary metabolism. Has also citrate synthase activity using as substrates acetyl-CoA and oxaloacetate. Plays a key role in the estabishment of invasive pulmonary aspergillosis.

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