6bqi | pdb_00006bqi

Structure of two-domain translational regulator Yih1 reveals a possible mechanism of action

spinqualitylabelsall models 6bqi, 3 NMR models Show:Asymmetric Unit Biological Assembly Drag the structure with the mouse to rotate   Export Animated Image   Print3D Structural highlights 6bqi is a 1 chain structure with sequence from Baker's yeast. Full experimental information is available from OCA. For a guided tour on the structure components use FirstGlance. Gene: YIH1, YCR059C, YCR59C (Baker's yeast) Resources: FirstGlance, OCA, PDBe, RCSB, PDBsum, ProSAT Function [YIH1_YEAST] Translational regulator that ensures constant high levels of translation under amino acid starvation. Plays a role as a negative regulator of the GCN2 kinase activity; impairs GCN1-mediated GCN2 activation, and hence GCN2-mediated eIF-2-alpha phosphorylation in amino acid-starved cells and subsequent down-regulation of protein synthesis (PubMed:15126500, PubMed:15937339, PubMed:24333428). In normal conditions, it resides in a actin complex and has no activity (PubMed:15126500).

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