6g3v | pdb_00006g3v

Crystal structure of human carbonic anhydrase I in complex with the inhibitor famotidine

spinqualitylabelsall models 6g3v, resolution 1.69Å Show:Asymmetric Unit Biological Assembly Drag the structure with the mouse to rotate   Export Animated Image   Print3D Structural highlights 6g3v is a 2 chain structure with sequence from Homo sapiens. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance. Ligands: FO9, GOL, ZN Activity: Carbonate dehydratase, with EC number 4.2.1.1 Resources: FirstGlance, OCA, PDBe, RCSB, PDBsum, ProSAT Function [CAH1_HUMAN] Reversible hydration of carbon dioxide. Can hydrates cyanamide to urea. Publication Abstract from PubMed Famotidine, an antiulcer drug incorporating a sulfamide motif, was investigated as carbonic anhydrase inhibitor (CAI). It acts as a nanomolar inhibitor of several human (hCA II, VI, VII and XII) and Helicobacter pylori CAs. The high resolution X-ray structures of famotidine bound to hCA I and II revealed interesting aspects related to its CA inhibition mechanism, offering the possibility to develop antibacterials with a novel mechanism of action. Famotidine, an Antiulcer Agent, Strongly Inhibits Helicobacter pylori and Human Carbonic Anhydrases.,Angeli A, Ferraroni M, Supuran CT ACS Med Chem Lett. 2018 Sep 4;9(10):1035-1038. doi:, 10.1021/acsmedchemlett.8b00334. eCollection 2018 Oct 11. PMID:30344913 From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.

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