Exophilin

spinqualitylabelsall models Caption for this structure Show:Asymmetric Unit Biological Assembly Drag the structure with the mouse to rotate   Export Animated Image   Print3D Function Exophilin (EXP) are Synaptotagmin-like membrane proteins which bind Ca+2 and phospholipids are involved in synaptic vesicle docking. EXP-1 or rabphilin-3A is a rab3 effector at the synapse. Rab3A is a GTP-binding protein of synaptic vesicle that regulates vesicle exocytosis. EXP-1 regulates synaptic vesicle traffic and does so at distinct stages of both the exocytotic and endocytotic pathways. Relevance EXP-1 is a diagnostically useful autoantigen for lymphocytic infundibulo-neurohypophysitis. Reduction of EXP-1 immunoreactivity was found in patients of Alzheimer disease.

3D structures of exophilin

Updated on 04-December-2018

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• Exophilin-1 or rabphilin-3A
  • Synaptotagmin, 4lt7 – rEXP C2A domain - rat
    
  • 2cm6, 2cm5 – rEXP C2B domain
    
  • 4np9, 4ns0 – rEXP C2A domain + inositol phosphate derivative
    
  • 5lo8 – rEXP C2B domain + inositol phosphate derivative
    
  • 5low, 5lob – rEXP C2B domain + SNAP25
    
• Exophilin-2 or synaptostagmin-like protein 4 or granuphilin
  • 2csz, 5x6t – hEXP RING domain - NMR
    
  • 3fdw – hEXP C2 domain
    
• Exophilin-3 or synaptostagmin-like protein 2A or melanophilin
  • 2zet – mEXP SLP homology domain + RAB-27A - mouse
    
  • 4kp3 – mEXP SLP globular tail domain + myosin-VA + RILPL2
    
  • 4lx2 – mEXP SLP globular tail domain + myosin-VA
    
• Exophilin-4 or synaptostagmin-like protein 2
  • 3bc1 – hEXP RAB-binding domain + RAB-27A
    

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Michal Harel, Alexander Berchansky