6eok | pdb_00006eok

Crystal structure of E. coli L-asparaginase II

spinqualitylabelsall models 6eok, resolution 2.50Å Show:Asymmetric Unit Biological Assembly Drag the structure with the mouse to rotate   Export Animated Image   Print3D Structural highlights 6eok is a 4 chain structure with sequence from Ecoli. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance. Ligands: ZN Related: 3eca, 1nns, 1jaz, 1ihd Gene: ansB, b2957, JW2924 (ECOLI) Activity: Asparaginase, with EC number 3.5.1.1 Resources: FirstGlance, OCA, PDBe, RCSB, PDBsum, ProSAT Publication Abstract from PubMed Resonance assignment and structural characterization of pharmacologically-relevant proteins promises to improve their understanding and safety by rational design. However, the PEG coating that is used to evade the immune system also causes these molecules to "evade" the standard structural biology methodologies. We here demonstrate that it is possible to obtain the resonance assignment and a reliable structural model of large PEGylated proteins through an integrated approach encompassing NMR and X-ray crystallography. Characterization of PEGylated asparaginase: new opportunities from NMR analysis of large pegylated therapeutics.,Cerofolini L, Giuntini S, Carlon A, Ravera E, Calderone V, Fragai M, Parigi G, Luchinat C Chemistry. 2018 Nov 21. doi: 10.1002/chem.201804488. PMID:30462348 From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.

Proteopedia Page Contributors and Editors (what is this?)

OCA