6cyo | pdb_00006cyo

Crystal structure of human UBE2A (RAD6A)

spinqualitylabelsall models 6cyo, resolution 1.85Å Show:Asymmetric Unit Biological Assembly Drag the structure with the mouse to rotate   Export Animated Image   Print3D Structural highlights 6cyo is a 1 chain structure. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance. Activity: E2 ubiquitin-conjugating enzyme, with EC number 2.3.2.23 Resources: FirstGlance, OCA, PDBe, RCSB, PDBsum, ProSAT Disease [UBE2A_HUMAN] X-linked intellectual disability, Nascimento type. The disease is caused by mutations affecting the gene represented in this entry. Function [UBE2A_HUMAN] Accepts ubiquitin from the E1 complex and catalyzes its covalent attachment to other proteins. In association with the E3 enzyme BRE1 (RNF20 and/or RNF40), it plays a role in transcription regulation by catalyzing the monoubiquitination of histone H2B at 'Lys-120' to form H2BK120ub1. H2BK120ub1 gives a specific tag for epigenetic transcriptional activation, elongation by RNA polymerase II, telomeric silencing, and is also a prerequisite for H3K4me and H3K79me formation. In vitro catalyzes 'Lys-11', as well as 'Lys-48'-linked polyubiquitination. Required for postreplication repair of UV-damaged DNA.

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