3hps | pdb_00003hps

Crystal structure of Mycobacterium tuberculosis LeuA complexed with ketoisocaproate (KIC)

spinqualitylabelsall models 3hps, resolution 1.80Å Show:Asymmetric Unit Biological Assembly Drag the structure with the mouse to rotate   Export Animated Image   Print3D Structural highlights 3hps is a 2 chain structure with sequence from Myctu. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance. Ligands: COI, GOL, LEU, ZN Related: 1sr9, 3fig, 3hpx, 3hpz, 3hq1 Gene: leuA, MT3813, MTV025.058, Rv3710 (MYCTU) Activity: 2-isopropylmalate synthase, with EC number 2.3.3.13 Resources: FirstGlance, OCA, PDBe, RCSB, PDBsum, ProSAT Function [LEU1_MYCTU] Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate) (By similarity). Evolutionary Conservation Check, as determined by ConSurfDB. You may read the explanation of the method and the full data available from ConSurf. See Also 2-isopropylmalate synthase

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