5g6m | pdb_00005g6m

Structure of Bacillus subtilis Nitric Oxide Synthase in complex with 7-((3-Aminomethyl)phenoxy)methyl)quinolin-2-amine

spinqualitylabelsall models 5g6m, resolution 1.77Å Show:Asymmetric Unit Biological Assembly Drag the structure with the mouse to rotate   Export Animated Image   Print3D Structural highlights 5g6m is a 1 chain structure with sequence from Bacsu. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance. Ligands: 9M9, CL, GOL, H4B, HEM Related: 5g65, 5g66, 5g67, 5g68, 5g69, 5g6a, 5g6b, 5g6c, 5g6d, 5g6e, 5g6f, 5g6g, 5g6h, 5g6i, 5g6j, 5g6k, 5g6l, 5g6n, 5g6o, 5g6p, 5g6q Activity: Nitric-oxide synthase (NAD(P)H-dependent), with EC number 1.14.13.165 Resources: FirstGlance, OCA, PDBe, RCSB, PDBsum, ProSAT Function [NOSO_BACSU] Catalyzes the production of nitric oxide. Publication Abstract from PubMed Nitric oxide (NO) is produced in Gram-positive pathogens Bacillus anthracis and Staphylococcus aureus by the bacterial isoform of nitric oxide synthase (NOS). Inhibition of bacterial nitric oxide synthase (bNOS) has been identified as a promising antibacterial strategy for targeting methicillin-resistant Staphylocoocus aureus1. One class of NOS inhibitors that demonstrates antimicrobial efficacy utilizes an aminoquinoline scaffold. Here we report on a variety of aminoquinolines that target the bacterial NOS active site, in part, by binding to a hydrophobic patch that is unique to bNOS. Through mutagenesis and crystallographic studies, our findings demonstrate that aminoquinolines are an excellent scaffold to further aid in the development of bNOS-specific inhibitors. Targeting Bacterial Nitric Oxide Synthase with Aminoquinoline-based Inhibitors.,Holden JK, Lewis MC, Cinelli MA, Abdullatif Z, Pensa AV, Silverman RB, Poulos TL Biochemistry. 2016 Sep 8. PMID:27607918 From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine. See Also Nitric Oxide Synthase

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