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CD69 (Cluster of Differentiation 69) is a human transmembrane calcium-dependent lectin protein. CD69 functions as a signal-transmitting receptor in lymphocytes natural killer cells and platelets. CD69 expression is induced upon activation of T-cell lymphocytes. [1] Na ion coordination site of CD69 C-type lectin-like domain dimer complex.[2] Water molecules are shown as red spheres.
- ↑ Natarajan K, Sawicki MW, Margulies DH, Mariuzza RA. Crystal structure of human CD69: a C-type lectin-like activation marker of hematopoietic cells. Biochemistry. 2000 Dec 5;39(48):14779-86. PMID:11101293
- ↑ Kolenko P, Skalova T, Vanek O, Stepankova A, Duskova J, Hasek J, Bezouska K, Dohnalek J. The high-resolution structure of the extracellular domain of human CD69 using a novel polymer. Acta Crystallogr Sect F Struct Biol Cryst Commun. 2009 Dec 1;65(Pt, 12):1258-60. Epub 2009 Nov 27. PMID:20054122 doi:10.1107/S1744309109043152
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3D structures of CD69
Updated on 11-February-2019
1e87, 1e8i, 1fm5, 3cck, 3hup – hCD69 C-type lectin-like domain – human
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