Cruzain

spinqualitylabelsall models Structure of cruzain catalytic domain complex with methylketone inhibitor (PDB entry 1me3) Show:Asymmetric Unit Biological Assembly Drag the structure with the mouse to rotate   Export Animated Image   Print3D Cruzain or cruzapain (Cru) is the major cysteine protease present in Trypanosoma cruzi which is the parasite causing Chagas disease. Relevance Cru inhibitors are being investigated for therapeutic use against Chagas disease. Structural highlights Cru catalytic triad is Cys-His-Asn and whole binding site (1me3).

3D structures of cruzain

Updated on 18-February-2019

1me3, 2aim, 1me3, 1me4 – Cru catalytic domain + methylketone inhibitor – Trypanosoma cruzi
1f29, 1f2a, 1f2b, 1f2c, 1ewo, 3lxs - Cru catalytic domain + vinyl sulfone derived inhibitor
1ewl, 1ewm – Cru catalytic domain + methylbutane inhibitor
1ewp - Cru catalytic domain + MOR-Leu-HPQ
4w5b, 4xui, 4qh6, 4pi3, 4klb, 3kku, 3i06, 2oz2, 1u9q – TcPRO + inhibitor
4w5c, 3iut, 3hd3 – TcPRO (mutant) + inhibitor

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