Dynamin

spinqualitylabelsall models Caption for this structure Show:Asymmetric Unit Biological Assembly Drag the structure with the mouse to rotate   Export Animated Image   Print3D Function Dynamin (DNM) is a GTPase which mediates endocytosis in membrane scission and organelle division. Dynamin 1-like mediates outer mitochondrial membrane fission. DNM is a multidomain GTPase. Mammalian genomes contain 3 DNM genes which show ca. 80% homology. DNM 1 is localized to neurons, DNM 2 is expressed ubiquitously and DNM 3 is found predominantly in the brain. The DNM 1 domain structure includes GTPase, middle, Plextrin homology, GTPase effector and phophotransferase regulation domains. Disease Mutations in DNM-2 cause centronuclear myopathy. Dynamin 3D structures See Dynamin 3D structures

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Michal Harel, Alexander Berchansky