Cytoglobin

spinqualitylabelsall models Human cytoglobin including the heme group complex with CO (PDB code 3ag0) Show:Asymmetric Unit Biological Assembly Drag the structure with the mouse to rotate   Export Animated Image   Print3D Function Cytoglobin (CYGB) is a globin which is ubiquitously expressed invertebrate tissues. CYGB is located in both cytoplasm and nucleus may provide O2 for enzymatic reactions and may be involved in NO-signaling pathways. Disease Loss of CYGB accelerates liver fibrosis and cancer development. Structural highlights CYGB heme group Fe has 6-fold coordination including the CO molecule as its 6th ligand. Whole binding site. Water molecules are shown as red spheres.

3D structures of cytoglobin

Updated on 20-February-2019

2dc3, 1v5h – hCYGB - human
1umo – hCYGB (mutant)
3ag0 – hCYGB + CO
1urv, 1ury, 1ut0, 1ux9 – hCYGB (mutant) + Fe(CN)6
4b3w – hCYGB (mutant) + CN + Fe(CN)6

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Dana M. Grass, Michal Harel, Alexander Berchansky, Joel L. Sussman