3zvr | pdb_00003zvr

Crystal structure of Dynamin

spinqualitylabelsall models 3zvr, resolution 3.10Å Show:Asymmetric Unit Biological Assembly Drag the structure with the mouse to rotate   Export Animated Image   Print3D Structural highlights 3zvr is a 1 chain structure with sequence from Buffalo rat. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance. Ligands: 1PE Related: 2aka Activity: Dynamin GTPase, with EC number 3.6.5.5 Resources: FirstGlance, OCA, PDBe, RCSB, PDBsum, ProSAT Function [DYN1_RAT] Microtubule-associated force-producing protein involved in producing microtubule bundles and able to bind and hydrolyze GTP. Most probably involved in vesicular trafficking processes. Involved in receptor-mediated endocytosis (By similarity). Publication Abstract from PubMed Dynamin-related proteins (DRPs) are multi-domain GTPases that function via oligomerization and GTP-dependent conformational changes to play central roles in regulating membrane structure across phylogenetic kingdoms. How DRPs harness self-assembly and GTP-dependent conformational changes to remodel membranes is not understood. Here we present the crystal structure of an assembly-deficient mammalian endocytic DRP, dynamin 1, lacking the proline-rich domain, in its nucleotide-free state. The dynamin 1 monomer is an extended structure with the GTPase domain and bundle signalling element positioned on top of a long helical stalk with the pleckstrin homology domain flexibly attached on its opposing end. Dynamin 1 dimer and higher order dimer multimers form via interfaces located in the stalk. Analysis of these interfaces provides insight into DRP family member specificity and regulation and provides a framework for understanding the biogenesis of higher order DRP structures and the mechanism of DRP-mediated membrane scission events. The crystal structure of dynamin.,Ford MG, Jenni S, Nunnari J Nature. 2011 Sep 18. doi: 10.1038/nature10441. PMID:21927001 From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine. See Also Dynamin 3D structures

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