Human Keto Acyl Reductase

==Your Heading Here (maybe something like 'Structure')==Crystal structure of heterotetrameric human ketoacyl reductase complexed with NAD and NADP

spinqualitylabelsall models Caption for this structure Show:Asymmetric Unit Biological Assembly Drag the structure with the mouse to rotate   Export Animated Image   Print3D This is a default text for your page Human Keto Acyl Reductase. Click above on edit this page to modify. Be careful with the < and > signs. You may include any references to papers as in: the use of JSmol in Proteopedia or to the article describing Jmol to the rescue. == Function == Keto acyl carrier protein reductase (KAR) is a heterotetrameric complex made from two different polypeptides: 17β-hydroxysteroid dehydrogenase type 8 (HSD17B8 or KE6, α-subunit) and carbonyl reductase type 4 (CBR4 or SDR45C1, β-subunit)9. it catalyzes the second step of the mitochondrial fatty acid synthesis (mtFAS) pathway. == Disease == Deficiency of the KAR or mtFAS leads to respiratory chain defects and mitochondrial dysfunction. Structural highlights NADP is bound in each of the four subunits in heterotetrameric structure. glycerol is also bound in the structure. This is a sample scene created with SAT to color by Group, and another to make a transparent representation of the protein. You can make your own scenes on SAT starting from scratch or loading and editing one of these sample scenes.

References

<PMID:25203508>

Proteopedia Page Contributors and Editors (what is this?)

Shiv K. Sah-Teli, Rajaram Venkatesan, Michal Harel