5y08 | pdb_00005y08

Solution structure of the apo doublet acyl carrier protein from prodigiosin biosynthesis

spinqualitylabelsall models 5y08, 20 NMR models Show:Asymmetric Unit Biological Assembly Drag the structure with the mouse to rotate   Export Animated Image   Print3D Structural highlights 5y08 is a 1 chain structure with sequence from Sers3. Full experimental information is available from OCA. For a guided tour on the structure components use FirstGlance. Gene: pigH (SERS3) Resources: FirstGlance, OCA, PDBe, RCSB, PDBsum, ProSAT Function [PIGH_SERS3] Involved in the biosynthesis of 4-methoxy-2,2'-bipyrrole-5-carbaldehyde (MBC), one of the terminal products involved in the biosynthesis of the red antibiotic prodigiosin (Pig). Carrier of the L-malonyl group (malonyl-S-PigH), which is decarboxylated by PigJ to yield a C2 carbanion acetyl-S-PigH. Then the pyrrolyl group of pyrrolyl-S-cysteinyl PigJ intermediate is captured by the C2 carbanion acetyl-S-PigH to yield the pyrrolyl-beta-ketoacyl-S-PigH. In the last step, PigH catalyzes the decarboxylative condensation between the pyrrolyl-beta-ketoacyl (pyrrolyl-beta-ketoacyl-S-PigH) and L-serine to yield 4-hydroxy-2,2'-bipyrrole-5-methanol (HBM).

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