4jul | pdb_00004jul

Crystal structure of H5N1 influenza virus hemagglutinin, clade 2.3.4

spinqualitylabelsall models 4jul, resolution 2.79Å Show:Asymmetric Unit Biological Assembly Drag the structure with the mouse to rotate   Export Animated Image   Print3D Structural highlights 4jul is a 12 chain structure with sequence from Influenza a virus (a/duck/laos/3295/2006(h5n1)). Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance. Ligands: NAG Gene: HA, hemagglutinin (Influenza A virus (A/duck/Laos/3295/2006(H5N1))) Resources: FirstGlance, OCA, PDBe, RCSB, PDBsum, ProSAT Function [Q00G25_9INFA] Binds to sialic acid-containing receptors on the cell surface, bringing about the attachment of the virus particle to the cell. This attachment induces virion internalization of about two third of the virus particles through clathrin-dependent endocytosis and about one third through a clathrin- and caveolin-independent pathway. Plays a major role in the determination of host range restriction and virulence. Class I viral fusion protein. Responsible for penetration of the virus into the cell cytoplasm by mediating the fusion of the membrane of the endocytosed virus particle with the endosomal membrane. Low pH in endosomes induces an irreversible conformational change in HA2, releasing the fusion hydrophobic peptide. Several trimers are required to form a competent fusion pore (By similarity).[RuleBase:RU003324][SAAS:SAAS000149_004_327643] See Also Hemagglutinin

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