Structural highlights
Function
[TAOK3_HUMAN] Serine/threonine-protein kinase that acts as a regulator of the p38/MAPK14 stress-activated MAPK cascade and of the MAPK8/JNK cascade. Acts as an activator of the p38/MAPK14 stress-activated MAPK cascade. In response to DNA damage, involved in the G2/M transition DNA damage checkpoint by activating the p38/MAPK14 stress-activated MAPK cascade, probably by mediating phosphorylation of upstream MAP2K3 and MAP2K6 kinases. Inhibits basal activity of MAPK8/JNK cascade and diminishes its activation in response epidermal growth factor (EGF).[1] [2] [3]
References
- ↑ Tassi E, Biesova Z, Di Fiore PP, Gutkind JS, Wong WT. Human JIK, a novel member of the STE20 kinase family that inhibits JNK and is negatively regulated by epidermal growth factor. J Biol Chem. 1999 Nov 19;274(47):33287-95. PMID:10559204
- ↑ Zhang W, Chen T, Wan T, He L, Li N, Yuan Z, Cao X. Cloning of DPK, a novel dendritic cell-derived protein kinase activating the ERK1/ERK2 and JNK/SAPK pathways. Biochem Biophys Res Commun. 2000 Aug 11;274(3):872-9. PMID:10924369 doi:https://dx.doi.org/10.1006/bbrc.2000.3244
- ↑ Raman M, Earnest S, Zhang K, Zhao Y, Cobb MH. TAO kinases mediate activation of p38 in response to DNA damage. EMBO J. 2007 Apr 18;26(8):2005-14. doi: 10.1038/sj.emboj.7601668. Epub 2007 Mar, 29. PMID:17396146 doi:https://dx.doi.org/10.1038/sj.emboj.7601668
