6fh1 | pdb_00006fh1

Protein arginine kinase McsB in the apo state

spinqualitylabelsall models 6fh1, resolution 1.70Å Show:Asymmetric Unit Biological Assembly Drag the structure with the mouse to rotate   Export Animated Image   Print3D Structural highlights 6fh1 is a 2 chain structure with sequence from Atcc 12980. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance. Ligands: EDO, FMT, IMD Gene: mcsB (ATCC 12980) Activity: Protein arginine kinase, with EC number 2.7.14.1 Resources: FirstGlance, OCA, PDBe, RCSB, PDBsum, ProSAT Function [MCSB_GEOSE] Catalyzes the specific phosphorylation of arginine residues in a large number of proteins. Is part of the bacterial stress response system, where it is involved in regulating the global heat shock repressor CtsR; phosphorylates arginine residues in the winged helix-turn-helix domain of CtsR, thereby preventing its binding to DNA and consequently inducing the expression of repressed genes. Protein arginine phosphorylation has a physiologically important role and is involved in the regulation of many critical cellular processes, such as protein homeostasis, motility, competence, and stringent and stress responses, by regulating gene expression and protein activity. Acts exclusively on Arg residues, since it cannot phosphorylate Tyr, Ser, Thr, His, Asp and Lys. See Also Arginine kinase 3D structures

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