Structural highlights
Publication Abstract from PubMedWith more than 50,000 members, terpenoids are one of the most important classes of natural products and show an enormous diversity. Due to their unique odors and specific bioactivities they already find wide application in the flavor, fragrance and pharma industries. Since most terpenoids can only be obtained by natural product extraction, the discovery of biosynthetic genes for the generation of terpene diversity becomes increasingly important. This study describes the discovery of three novel sesquiterpene synthases from Streptomyces chartreusis with preference for the formation of germacradiene-11-ol, alpha-eudesmol and alpha-amorphene respectively. The alpha-eudesmol synthase showed formation of 10-epi-delta-eudesmol and elemol as side products. Eudesmol-isomers are known to have repellent activity, which makes this enzyme a potential catalyst for products for the prevention of mosquito-related disease. The determination of the structure of the apo-enzyme of alpha-eudesmol synthase from S. chartreusis provides the first structural insights into an eudesmol-forming enzyme. Discovery of three novel sesquiterpene synthases from Streptomyces chartreusis NRRL 3882 and crystal structure of an alpha-eudesmol synthase.,Kracht ON, Correia Cordeiro RS, Hakansson M, Stockmann J, Sander D, Bandow J, Senges CHR, Logan DT, Kourist R J Biotechnol. 2019 Mar 27. pii: S0168-1656(19)30079-3. doi:, 10.1016/j.jbiotec.2019.03.006. PMID:30928538[1] From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine. References
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