4olf | pdb_00004olf

Crystal Structure of Prolyl-tRNA synthetase (ProRS, Proline--tRNA ligase)from Plasmodium falciparum in complex with Halofuginone and AMPPNP

spinqualitylabelsall models 4olf, resolution 2.90Å Show:Asymmetric Unit Biological Assembly Drag the structure with the mouse to rotate   Export Animated Image   Print3D Structural highlights 4olf is a 1 chain structure with sequence from Plaf7. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance. Ligands: ANP, EDO, HFG, NA, SO4 Related: 4ncx Gene: proRS, PFL0670c (PLAF7) Activity: Proline--tRNA ligase, with EC number 6.1.1.15 Resources: FirstGlance, OCA, PDBe, RCSB, PDBsum, ProSAT Function [SYP_PLAF7] Catalyzes the attachment of proline to tRNA(Pro) in a two-step reaction: proline is first activated by ATP to form Pro-AMP and then transferred to the acceptor end of tRNA(Pro) (By similarity). Functions in trans to edit the amino acid moiety from incorrectly charged Ala-tRNA(Pro). Has no activity on correctly charged Pro-tRNA(Pro) or Ala-tRNA(Ala). See Also Aminoacyl tRNA synthetase 3D structures

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