Calcineurin

spinqualitylabelsall models Human calcineurin regulatory subunit B (magenta) and catalytic subunit A (cyan) complex with Ca+2 (green), Fe +3 (orange) and Zn+2 (grey) ions, 1aui Show:Asymmetric Unit Biological Assembly Drag the structure with the mouse to rotate   Export Animated Image   Print3D Function Calcineurin (CN) is a eukaryotic calcium-dependent serine/threonine protein phosphatase 2B which dephosphorylates serine/threonine residues. CN activates T cells of the immune system. It participates in Ca+2-dependent signal transduction pathways. For more details see Group:MUZIC:Calcineurin. Relevance CN inhibitors are used as drugs in cases of rheumatic diseases, schizophrenia and diabetes. It is inhibited by immunosuppressant drugs like cyclosporine. Structural highlights It contains a calmodulin-binding catalytic subunit A and a Ca+2-binding regulatory subunit B. There are 2 metal ions in CN active site (molecules of water are shown as red spheres). 3D structures of calcineurin Calcineurin 3D structures

References

See Group:MUZIC:Calcineurin.

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Michal Harel, Alexander Berchansky