4tvm | pdb_00004tvm

Structure of Citrate Synthase from Mycobacterium tuberculosis

spinqualitylabelsall models 4tvm, resolution 2.60Å Show:Asymmetric Unit Biological Assembly Drag the structure with the mouse to rotate   Export Animated Image   Print3D Structural highlights 4tvm is a 1 chain structure with sequence from Myctu. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance. Ligands: OAA Gene: RVBD_0896 (MYCTU) Activity: Citrate (Si)-synthase, with EC number 2.3.3.1 Resources: FirstGlance, OCA, PDBe, RCSB, PDBsum, ProSAT Publication Abstract from PubMed The tricarboxylic acid (TCA) cycle is a central metabolic pathway of all aerobic organisms and is responsible for the synthesis of many important precursors and molecules. TCA cycle plays a key role in the metabolism of M. tuberculosis and is involved in the adaptation process of the bacteria to the host immune response. We present here the first crystal structures of M. tuberculosis malate dehydrogenase and citrate synthase, two consecutive enzymes of the tricarboxylic acid cycle, at 2.6 A and 1.5 A resolution, respectively. General analogies and local differences with the previously reported homologous protein structures are described. This article is protected by copyright. All rights reserved. Structures of citrate synthase and malate dehydrogenase of mycobacterium tuberculosis.,Ferraris DM, Spallek R, Oehlmann W, Singh M, Rizzi M Proteins. 2014 Dec 18. doi: 10.1002/prot.24743. PMID:25524525 From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine. See Also Citrate Synthase

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