| Structural highlights
6gr8 is a 2 chain structure with sequence from Human. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance.
| | Ligands: | F8Z |
| NonStd Res: | SEP, TPO |
| Gene: | AURKC, AIE2, AIK3, AIRK3, ARK3, STK13 (HUMAN), INCENP (HUMAN) |
| Activity: | Non-specific serine/threonine protein kinase, with EC number 2.7.11.1 |
| Resources: | FirstGlance, OCA, PDBe, RCSB, PDBsum, ProSAT |
Disease
[AURKC_HUMAN] Male infertility due to large-headed multiflagellar polyploid spermatozoa. The disease is caused by mutations affecting the gene represented in this entry.
Function
[AURKC_HUMAN] Serine/threonine-protein kinase component of the chromosomal passenger complex (CPC), a complex that acts as a key regulator of mitosis. The CPC complex has essential functions at the centromere in ensuring correct chromosome alignment and segregation and is required for chromatin-induced microtubule stabilization and spindle assembly. Plays also a role in meiosis and more particularly in spermatogenesis. Has redundant cellular functions with AURKB and can rescue an AURKB knockdown. Like AURKB, AURKC phosphorylates histone H3 at 'Ser-10' and 'Ser-28'. AURKC phosphorylates the CPC complex subunits BIRC5/survivin and INCENP leading to increased AURKC activity. Phosphorylates TACC1, another protein involved in cell division, at 'Ser-228'.[1] [2] [3] [4] [5] [6] [7] [INCE_HUMAN] Component of the chromosomal passenger complex (CPC), a complex that acts as a key regulator of mitosis. The CPC complex has essential functions at the centromere in ensuring correct chromosome alignment and segregation and is required for chromatin-induced microtubule stabilization and spindle assembly. Probably acts through association with AURKB or AURKC. Seems to bind directly to microtubules. Controls the kinetochore localization of BUB1.[8] [9] [10]
References
- ↑ Li X, Sakashita G, Matsuzaki H, Sugimoto K, Kimura K, Hanaoka F, Taniguchi H, Furukawa K, Urano T. Direct association with inner centromere protein (INCENP) activates the novel chromosomal passenger protein, Aurora-C. J Biol Chem. 2004 Nov 5;279(45):47201-11. Epub 2004 Aug 16. PMID:15316025 doi:https://dx.doi.org/10.1074/jbc.M403029200
- ↑ Sasai K, Katayama H, Stenoien DL, Fujii S, Honda R, Kimura M, Okano Y, Tatsuka M, Suzuki F, Nigg EA, Earnshaw WC, Brinkley WR, Sen S. Aurora-C kinase is a novel chromosomal passenger protein that can complement Aurora-B kinase function in mitotic cells. Cell Motil Cytoskeleton. 2004 Dec;59(4):249-63. doi: 10.1002/cm.20039. PMID:15499654 doi:https://dx.doi.org/10.1002/cm.20039
- ↑ Yan X, Wu Y, Li Q, Cao L, Liu X, Saiyin H, Yu L. Cloning and characterization of a novel human Aurora C splicing variant. Biochem Biophys Res Commun. 2005 Mar 4;328(1):353-61. doi:, 10.1016/j.bbrc.2004.12.168. PMID:15670791 doi:https://dx.doi.org/10.1016/j.bbrc.2004.12.168
- ↑ Yan X, Cao L, Li Q, Wu Y, Zhang H, Saiyin H, Liu X, Zhang X, Shi Q, Yu L. Aurora C is directly associated with Survivin and required for cytokinesis. Genes Cells. 2005 Jun;10(6):617-26. doi: 10.1111/j.1365-2443.2005.00863.x. PMID:15938719 doi:https://dx.doi.org/10.1111/j.1365-2443.2005.00863.x
- ↑ Avo Santos M, van de Werken C, de Vries M, Jahr H, Vromans MJ, Laven JS, Fauser BC, Kops GJ, Lens SM, Baart EB. A role for Aurora C in the chromosomal passenger complex during human preimplantation embryo development. Hum Reprod. 2011 Jul;26(7):1868-81. doi: 10.1093/humrep/der111. Epub 2011 Apr 14. PMID:21493633 doi:https://dx.doi.org/10.1093/humrep/der111
- ↑ Gabillard JC, Ulisse S, Baldini E, Sorrenti S, Cremet JY, Coccaro C, Prigent C, D'Armiento M, Arlot-Bonnemains Y. Aurora-C interacts with and phosphorylates the transforming acidic coiled-coil 1 protein. Biochem Biophys Res Commun. 2011 May 20;408(4):647-53. doi:, 10.1016/j.bbrc.2011.04.078. Epub 2011 Apr 21. PMID:21531210 doi:https://dx.doi.org/10.1016/j.bbrc.2011.04.078
- ↑ Sasai K, Katayama H, Hawke DH, Sen S. Aurora-C Interactions with Survivin and INCENP Reveal Shared and Distinct Features Compared with Aurora-B Chromosome Passenger Protein Complex. PLoS One. 2016 Jun 22;11(6):e0157305. doi: 10.1371/journal.pone.0157305., eCollection 2016. PMID:27332895 doi:https://dx.doi.org/10.1371/journal.pone.0157305
- ↑ Li X, Sakashita G, Matsuzaki H, Sugimoto K, Kimura K, Hanaoka F, Taniguchi H, Furukawa K, Urano T. Direct association with inner centromere protein (INCENP) activates the novel chromosomal passenger protein, Aurora-C. J Biol Chem. 2004 Nov 5;279(45):47201-11. Epub 2004 Aug 16. PMID:15316025 doi:https://dx.doi.org/10.1074/jbc.M403029200
- ↑ Honda R, Korner R, Nigg EA. Exploring the functional interactions between Aurora B, INCENP, and survivin in mitosis. Mol Biol Cell. 2003 Aug;14(8):3325-41. Epub 2003 May 29. PMID:12925766 doi:https://dx.doi.org/10.1091/mbc.E02-11-0769
- ↑ Qi W, Tang Z, Yu H. Phosphorylation- and polo-box-dependent binding of Plk1 to Bub1 is required for the kinetochore localization of Plk1. Mol Biol Cell. 2006 Aug;17(8):3705-16. Epub 2006 Jun 7. PMID:16760428 doi:https://dx.doi.org/10.1091/mbc.E06-03-0240
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