1e12 | pdb_00001e12

Halorhodopsin, a light-driven chloride pump

spinqualitylabelsall models 1e12, resolution 1.80Å Show:Asymmetric Unit Biological Assembly Drag the structure with the mouse to rotate   Export Animated Image   Print3D Structural highlights 1e12 is a 1 chain structure with sequence from Halobacterium salinarum. The March 2002 RCSB PDB Molecule of the Month feature on Bacteriorhodopsin by David S. Goodsell is 10.2210/rcsb_pdb/mom_2002_3. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance. Ligands: CL, K, OLC, PLM, RET Related: 1brr Resources: FirstGlance, OCA, PDBe, RCSB, PDBsum, ProSAT Function [BACH_HALSA] Halorhodopsin is a light-driven chloride pump. Evolutionary Conservation Check, as determined by ConSurfDB. You may read the explanation of the method and the full data available from ConSurf. Publication Abstract from PubMed Halorhodopsin, an archaeal rhodopsin ubiquitous in Haloarchaea, uses light energy to pump chloride through biological membranes. Halorhodopsin crystals were grown in a cubic lipidic phase, which allowed the x-ray structure determination of this anion pump at 1.8 angstrom resolution. Halorhodopsin assembles to trimers around a central patch consisting of palmitic acid. Next to the protonated Schiff base between Lys(242) and the isomerizable retinal chromophore, a single chloride ion occupies the transport site. Energetic calculations on chloride binding reveal a combination of ion-ion and ion-dipole interactions for stabilizing the anion 18 angstroms below the membrane surface. Ion dragging across the protonated Schiff base explains why chloride and proton translocation modes are mechanistically equivalent in archaeal rhodopsins. Structure of the light-driven chloride pump halorhodopsin at 1.8 A resolution.,Kolbe M, Besir H, Essen LO, Oesterhelt D Science. 2000 May 26;288(5470):1390-6. PMID:10827943 From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine. See Also Bacteriorhodopsin 3D structures Rhodopsin

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