6eyf | pdb_00006eyf

Butyrylcolinesterase expressed in CHO cells co-crystallised with a rivastigmine analogue

spinqualitylabelsall models 6eyf, resolution 2.60Å Show:Asymmetric Unit Biological Assembly Drag the structure with the mouse to rotate   Export Animated Image   Print3D Structural highlights 6eyf is a 1 chain structure with sequence from Human. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance. Ligands: BY2, GOL, NAG, SO4 NonStd Res: BXT Gene: BCHE, CHE1 (HUMAN) Activity: Cholinesterase, with EC number 3.1.1.8 Resources: FirstGlance, OCA, PDBe, RCSB, PDBsum, ProSAT Disease [CHLE_HUMAN] Defects in BCHE are the cause of butyrylcholinesterase deficiency (BChE deficiency) [MIM:177400]. BChE deficiency is a metabolic disorder characterized by prolonged apnoea after the use of certain anesthetic drugs, including the muscle relaxants succinylcholine or mivacurium and other ester local anesthetics. The duration of the prolonged apnoea varies significantly depending on the extent of the enzyme deficiency. BChE deficiency is a multifactorial disorder. The hereditary condition is transmitted as an autosomal recessive trait. Function [CHLE_HUMAN] Esterase with broad substrate specificity. Contributes to the inactivation of the neurotransmitter acetylcholine. Can degrade neurotoxic organophosphate esters.

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