4y61 | pdb_00004y61

Crystal structure of the complex between Slitrk2 LRR1 and PTP delta Ig1-Fn1

spinqualitylabelsall models 4y61, resolution 3.36Å Show:Asymmetric Unit Biological Assembly Drag the structure with the mouse to rotate   Export Animated Image   Print3D Structural highlights 4y61 is a 2 chain structure with sequence from Lk3 transgenic mice. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance. Ligands: NAG Gene: Ptprd (LK3 transgenic mice), Slitrk2 (LK3 transgenic mice) Activity: Protein-tyrosine-phosphatase, with EC number 3.1.3.48 Resources: FirstGlance, OCA, PDBe, RCSB, PDBsum, ProSAT Function [SLIK2_MOUSE] Suppresses neurite outgrowth. Publication Abstract from PubMed Selective binding between pre- and postsynaptic adhesion molecules can induce synaptic differentiation. Here we report the crystal structure of a synaptogenic trans-synaptic adhesion complex between Slit and Trk-like family member 2 (Slitrk2) and receptor protein tyrosine phosphatase (RPTP) delta. The structure and site-directed mutational analysis revealed the structural basis of splicing-dependent adhesion between Slitrks and type IIa RPTPs for inducing synaptic differentiation. Structure of Slitrk2-PTPdelta complex reveals mechanisms for splicing-dependent trans-synaptic adhesion.,Yamagata A, Sato Y, Goto-Ito S, Uemura T, Maeda A, Shiroshima T, Yoshida T, Fukai S Sci Rep. 2015 May 19;5:9686. doi: 10.1038/srep09686. PMID:25989451 From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine. See Also Tyrosine phosphatase

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