6osw | pdb_00006osw

An order-to-disorder structural switch activates the FoxM1 transcription factor

spinqualitylabelsall models 6osw, 10 NMR models Show:Asymmetric Unit Biological Assembly Drag the structure with the mouse to rotate   Export Animated Image   Print3D Structural highlights 6osw is a 2 chain structure with sequence from Brachidanio rerio. Full experimental information is available from OCA. For a guided tour on the structure components use FirstGlance. Gene: foxm1, foxm1l (Brachidanio rerio) Resources: FirstGlance, OCA, PDBe, RCSB, PDBsum, ProSAT Publication Abstract from PubMed Intrinsically disordered transcription factor transactivation domains (TADs) function through structural plasticity, adopting ordered conformations when bound to transcriptional co-regulators. Many transcription factors contain a negative regulatory domain (NRD) that suppresses recruitment of transcriptional machinery through autoregulation of the TAD. We report the solution structure of an autoinhibited NRD-TAD complex within FoxM1, a critical activator of mitotic gene expression. We observe that while both the FoxM1 NRD and TAD are primarily intrinsically disordered domains, they associate and adopt a structured conformation. We identify how Plk1 and Cdk kinases cooperate to phosphorylate FoxM1, which releases the TAD into a disordered conformation that then associates with the TAZ2 or KIX domains of the transcriptional co-activator CBP. Our results support a mechanism of FoxM1 regulation in which the TAD undergoes switching between disordered and different ordered structures. An order-to-disorder structural switch activates the FoxM1 transcription factor.,Marceau AH, Brison CM, Nerli S, Arsenault HE, McShan AC, Chen E, Lee HW, Benanti JA, Sgourakis NG, Rubin SM Elife. 2019 May 28;8. pii: 46131. doi: 10.7554/eLife.46131. PMID:31134895 From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.

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