Elastase

spinqualitylabelsall models Pig elastase (cyan, green) complex with chymotrypsin/elastase isoinhibitor (magenta, yellow) (PDB code 1eai). Show:Asymmetric Unit Biological Assembly Drag the structure with the mouse to rotate   Export Animated Image   Print3D Elastase (ELA) is a chymotrypsin-like serine protease which breaks down proteins. The ELAs are numbered according to their genes. Panceatic ELA cleaves proteins at the carboxyl-terminal side of small neutral amino acids. It cleaves Ala-Ala and Ala-Gly bonds. For additional details see Protease Serine Proteases. Relevance ELA2 (or PMN-ELA) is secreted by neutrophils during inflammation. Disease Pulmonary emphysema is caused by the destruction of elastic fibre by elastase. Mutations in ELA2 are linked to the genetic disorder cyclic hematopoeiesis. Neutrophil elastase is involved in the blistering in bullose pemphigoid. Structural highlights Pig elastase (cyan, green) complex with chymotrypsin/elastase isoinhibitor (magenta, yellow) (PDB code 1eai). ELA catalytic triad is Ser-His-Asp. 3D structures of elastase Elastase 3D structures

Proteopedia Page Contributors and Editors (what is this?)

Alexander Berchansky, Guido Hansen, Jaime Prilusky, Michal Harel