6mqa | pdb_00006mqa

Structure of HIV-1 CA P207S

spinqualitylabelsall models 6mqa, resolution 3.20Å Show:Asymmetric Unit Biological Assembly Drag the structure with the mouse to rotate   Export Animated Image   Print3D Structural highlights 6mqa is a 1 chain structure. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance. Ligands: CL, IOD Resources: FirstGlance, OCA, PDBe, RCSB, PDBsum, ProSAT Publication Abstract from PubMed The human antiviral protein MxB is a restriction factor that fights HIV infection. Previous experiments have demonstrated that MxB targets the HIV capsid, a protein shell that protects the viral genome. To make the conical-shaped capsid, HIV CA proteins are organized into a lattice composed of hexamer and pentamer building blocks, providing many interfaces for host proteins to recognize. Through extensive biochemical and biophysical studies and molecular dynamics simulations, we show that MxB is targeting the HIV capsid by recognizing the region created at the intersection of three CA hexamers. We are further able to map this interaction to a few CA residues, located in a negatively charged well at the interface between the three CA hexamers. This work provides detailed residue-level mapping of the targeted capsid interface and how MxB interacts. This information could inspire the development of capsid-targeting therapies for HIV. MxB Restricts HIV-1 by Targeting the Tri-hexamer Interface of the Viral Capsid.,Smaga SS, Xu C, Summers BJ, Digianantonio KM, Perilla JR, Xiong Y Structure. 2019 May 10. pii: S0969-2126(19)30137-6. doi:, 10.1016/j.str.2019.04.015. PMID:31155311 From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.

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