Eukaryotic initiation factor

spinqualitylabelsall models Human initiation factor EIF4E complex with 7-methyl GPPPA 1ipb Show:Asymmetric Unit Biological Assembly Drag the structure with the mouse to rotate   Export Animated Image   Print3D Function Eukaryotic initiation factors (EIF) are involved in the initiation of protein translation. They form a complex with the small subunit of the ribosome and Met-tRNA which scans the mRNA and recognizes the initiation codon AUG. For details on EIF4 see C-terminal portion of human eIF4GI. Disease Overexpression of individual subunits of eIF3 may cause malignant transformation . Overexpression of eIF4g is implicated in breast cancer. Structural insights EIF domains include the N terminal domain (NTD), C terminal domain (CTD), RNA recognition domain, middle domain, PAZ domain of EIF2C and a protein-protein interaction domain (PCI) of EIF3. P1-7-METHYLGUANOSINE-P3-ADENOSINE-5',5'-TRIPHOSPHATE (7-methyl GPPPA) binding site. Water molecules shown as red spheres. 3D structures of eukaryotic initiation factor Eukaryotic initiation factor 3D structures

Proteopedia Page Contributors and Editors (what is this?)

Michal Harel, Alexander Berchansky, Joel L. Sussman