Exportin

spinqualitylabelsall models Structure of yeast exportin-5 (magenta) complex with GTPaseRan (cyan), Mg+2 (green) and RNA (PDB code 3icq). Show:Asymmetric Unit Biological Assembly Drag the structure with the mouse to rotate   Export Animated Image   Print3D Exportins (XPO) or chromosomal maintenance protein mediate the nuclear export of cellular proteins with a leucine-rich export signal (NES) and RNA. XPO is regulated by GTPaseRan. RanGTP bind to XPO forming a ternary complex with the exported protein. The complex diffuses through the nuclear core complex to the cytoplasm and then dissociates. XPO-t exports tRNA from the nucleus. Structural highlights Yeast exportin-5 with GTPaseRan, Mg+2 and RNA. GTP binding site. Mg coordination site (PDB code 3icq). 3D structures of exportin Exportin 3D structures

3D structures of exportin

Updated on 25-June-2019

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• XPO-1
  • 3icq, Exportin 3D structures – hXPO – human
    
  • 1w9c – hXPO C terminal 6 heat repeats
    
  • 3vyc – yXPO (mutant) - yeast
    
  • 4fgv – XPO – Chaetomium thermophilum
    
• XPO-1 complexes
  • 3gb8 – hXPO + RNA U transporter 1
    
  • 3gjx – hXPO + RNA U transporter 1 + RAN
    
  • 5dis – hXPO + RAN + RNA U transporter 1 + MBP
    
  • 3m1i, 4gpt, 4gmx, 4hat, 4hb2, 5jlj – yXPO (mutant) + RAN + RANBP1
    
  • 3wyf – yXPO + RAN + RANBP1
    
  • 3wyg – yXPO + RAN + PKI-α
    
  • 5zpu, 5ytb, 5yst, 5uro - yXPO (mutant) + RAN + RANBP1 + GTP
    
  • 5ysu - yXPO (mutant) + RAN + RANBP1 + GTP + plumbagin
    
  • 4hau, 4hav, 4haw, 4hax, 4hay, 4haz, 4hb0, 4hb3, 4hb4 – yXPO (mutant) + RAN + RANBP1 + antibiotic
    
  • 5dh9, 5dha, 5dhf, 5di9, 5uwj, 5dif - yXPO (mutant) + RAN + RANBP1 + signal peptide
    
  • 5uwo, 5uwp, 5uwq, 5uwr, 5uws, 5uwt, 5uwu, 5uww, 5uwi, 5uwh - yXPO + RAN + RANBP1 + signal peptide
    
  • 6cit, 6a38 - yXPO + RAN + RANBP1 + NS2 peptide
    
  • 6a3a, 6a3b, 6a3c, 6a3e - yXPO (mutant) + RAN + RANBP1 + NS2 peptide
    
  • 5xoj - yXPO (mutant) + GSP1P + PKI-a + NUP42 peptide + GTP
    
  • 3nby, 3nbz, 3nc0 – mXPO + RNA U transporter 1 + RANBP1 - mouse
    
  • 3nc1 – mXPO + RANBP1
    
  • 2l1l – hXPO residues 504-630 + PKI-α - NMR
    
• XPO-t
  • 3ibv – fyXPO – fission yeast
    
  • 3icq – fyXPO + RAN homolog + RNA
    
• XPO-4
  • 5dlq – mXPO (mutant) + RAN + EIF5A1
    
• XPO-5
  • 5yu7 – hXPO
    
  • 5yu6 – hXPO + peptide + RAN
    
  • 3a6p – hXPO + peptide + pre-microRNA
    

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Michal Harel, Alexander Berchansky