Structural highlights
5n6f is a 1 chain structure with sequence from Zymmo. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance.
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| Ligands: | DMS, GUN, PEG, PGE, ZN |
| Gene: | tgt, ZMO0363 (ZYMMO) |
| Activity: | tRNA-guanine(34) transglycosylase, with EC number 2.4.2.29 |
| Resources: | FirstGlance, OCA, PDBe, RCSB, PDBsum, ProSAT |
Function
[TGT_ZYMMO] Exchanges the guanine residue with 7-aminomethyl-7-deazaguanine in tRNAs with GU(N) anticodons (tRNA-Asp, -Asn, -His and -Tyr). After this exchange, a cyclopentendiol moiety is attached to the 7-aminomethyl group of 7-deazaguanine, resulting in the hypermodified nucleoside queuosine (Q) (7-(((4,5-cis-dihydroxy-2-cyclopenten-1-yl)amino)methyl)-7-deazaguanosine).[HAMAP-Rule:MF_00168]
