5v48 | pdb_00005v48

Soluble rabbit neprilysin in complex with thiorphan

spinqualitylabelsall models 5v48, resolution 3.00Å Show:Asymmetric Unit Biological Assembly Drag the structure with the mouse to rotate   Export Animated Image   Print3D Structural highlights 5v48 is a 2 chain structure with sequence from European rabbit. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance. Ligands: NAG, TIO, ZN Related: 4xbh Gene: MME (European rabbit) Activity: Neprilysin, with EC number 3.4.24.11 Resources: FirstGlance, OCA, PDBe, RCSB, PDBsum, ProSAT Function [NEP_RABIT] Thermolysin-like specificity, but is almost confined on acting on polypeptides of up to 30 amino acids. Biologically important in the destruction of opioid peptides such as Met- and Leu-enkephalins by cleavage of a Gly-Phe bond. Able to cleave angiotensin-1, angiotensin-2 and angiotensin 1-9. Involved in the degradation of atrial natriuretic factor (ANF). Displays UV-inducible elastase activity toward skin preelastic and elastic fibers.[UniProtKB:P08473] See Also Neprilysin

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