Flagellin

spinqualitylabelsall models Glycosylated flagellin (pink, yellow) complex with TLR5 (grey, green) (PDB code 3v47) Show:Asymmetric Unit Biological Assembly Drag the structure with the mouse to rotate   Export Animated Image   Print3D Function Flagellin (Fla) from Salmonella typhimurium is the major molecular trigger by which the pathogen activates gut epithelial proinflammatory gene expression. Toll-like receptor 5 (TLR5) recognizes bacterial Fla and this association mediates the innate immune response to the bacteria. Structural highlights Fla and TLR5 binding interface is composed in part between the long helices of Fla and the ascending lateral surface of TLR5. 3D Structures of flagellin Flagellin 3D structures

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Michal Harel, Alexander Berchansky, Joel L. Sussman