Ketohexokinase

spinqualitylabelsall models Human ketohexokinase complex with ihibitor and sulfate (PDB entry 3q92) Show:Asymmetric Unit Biological Assembly Drag the structure with the mouse to rotate   Export Animated Image   Print3D Function Ketohexokinase (KHK) also known as hepatic fructokinase catalyzes the phosphorylation of fructose to fructose-1-phosphate using ATP as phosphate source in the liver. The HKH gene is spliced to HKH-A and the more active HKH-C. KHK acts in the first step of fructose metabolism. Disease HKH deficiency causes the essential fructosuria disorder. Structural highlights Human KHK inhibitor interacts with the 2 monomers. Water molecule shown as red sphere.

3D structures of ketohexokinase

2hlz, 2hqq, 3b3l – hKHK – human
2hw1, 3nbv – hKHK + AMPPNP + fructose
3nbw – hKHK + pyrazole derivative
3nc2, 3nc9, 3nca, 3ro4, 3q92, 3qa2, 3qai, 5wbm, 5wbo, 5wbp, 5wbq, 5wbr, 5wbz – hKHK + inhibitor

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