6a8o | pdb_00006a8o

Crystal structures of the serine protease domain of murine plasma kallikrein with peptide inhibitor mupain-1-16

spinqualitylabelsall models 6a8o, resolution 2.77Å Show:Asymmetric Unit Biological Assembly Drag the structure with the mouse to rotate   Export Animated Image   Print3D Structural highlights 6a8o is a 3 chain structure. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance. Ligands: MAN, MRZ Activity: Plasma kallikrein, with EC number 3.4.21.34 Resources: FirstGlance, OCA, PDBe, RCSB, PDBsum, ProSAT Function [KLKB1_MOUSE] The enzyme cleaves Lys-Arg and Arg-Ser bonds. It activates, in a reciprocal reaction, factor XII after its binding to a negatively charged surface. It also releases bradykinin from HMW kininogen and may also play a role in the renin-angiotensin system by converting prorenin into renin.

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