Glycosyltransferase 3D structures

3D structures of glycosyltransferase

Updated on 16-July-2019

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• Cyclodextrin GT (CGT)
  • 1cxi, 1cdg, 1cgt, 1cgu - BcCGT – Bacillus circulans
  • 1tcm, 4cgt, 7cgt, 1kck, 1kcl, 1ot1, 1ot2, 1pez, 1pj9, 1v3j, 1v3k, 1cgv, 1cgw - BcCGT (mutant)
  • 1ciu – TtCGT – Thermoanaerobacterium thermosulfurigenes
  • 3bmv, 3bmw – TtCGT (mutant)
    
  • 1cyg – CGT – Geobacillus stearothermophilus
    
  • 1d7f - BaCGT (mutant) – Bacillus
    
  • 1pam - BaCGT
    
  • 4jcl - PmCGT – Paenibacillus macerans
    
  • 6aij - PmCGT (mutant)
    
• CGT binary complexes
  • 1cxe, 1cxh – BcCGT + substrate
  • 1cxf, 5cgt, 8cgt, 9cgt, 1cxk, 1eo5, 1eo7 - BcCGT (mutant) + substrate
  • 3cgt - BcCGT (mutant) + β-cyclodextrin
  • 1d3c - BcCGT (mutant) + γ-cyclodextrin
  • 6cgt - BcCGT (mutant) + HOXA
  • 2dij, 1dtu - BcCGT (mutant) + inhibitor
  • 1cxl - BcCGT (mutant) + reaction intermediate
  • 2cxg, 1ukq – BcCGT + acarbose-derivative
  • 1uks, 1ukt, 1v3l, 1v3m – BcCGT (mutant) + acarbose-derivative
    
  • 1ded - BaCGT (mutant) + acarbose
    
  • 1i75 – BaCGT + deoxyjirimycin
    
  • 1a47 – TtCGT + inhibitor
• Maltose GT
  • 1gju, 1lwh – TmMCG – Thermotoga maritima
  • 1gjw – TmMCG + maltose
  • 1lwj - TmMGT + acarbose
• Human GT
  • 1lz0 – hGT A - hGT A catalytic domain + inhibitor
  • 1r7y, 1r81 - hGT A catalytic domain + inhibitor + UDP-derivative
  • 1lz7 – hGT B catalytic domain
  • 1r7u, 1r7x - hGT B catalytic domain + inhibitor
  • 1r80, 1r82 - hGT B catalytic domain + inhibitor + UDP-derivative
  • 1lzi – hGT A catalytic domain + UDP + H antigen acceptor
  • 1lzj – hGT B catalytic domain + UDP + H antigen acceptor
  • 1r7t, 1r7v - hGT ABO(H) + inhibitor
  • 1wt0, 1wsz, 1wt3, 2o1f, 2o1g, 3i0c, 3i0h, 1xz6, 2i7b – hGT ABO(H) (mutant)
  • 1wt1, 1wt2, 2o1h, 3i0d, 3i0i, 2y7a - hGT ABO(H) (mutant) + UDP
  • 3i0e, 3i0j - hGT ABO(H) (mutant) + H-antigen
  • 3i0f, 3i0k - hGT ABO(H) (mutant) + H-antigen + UDP
  • 3i0g, 3i0l - hGT ABO(H) (mutant) + DA + UDP-Gal
• Oleandomycin GT
  • 2iya, 2iyf, 4m60, 4m7p – SaGT – Strepromyces antibioticus
    
  • 4m83 – SaGT + UDP + erythromycin
    
• Hydroquinone GT
  • 2vce – AtGT – Arabidopsis thaliana
    
  • 2vch, 2vg8 – AtGT + UDP
• UDP GT
  • 5tme, 5tmb – rGT OS 79 + UDP - rice
    
  • 6bk0, 6bk1, 6bk2 - rGT OS 79 (mutant) + UDP
    
  • 5tmd, 6bk3 – rGT OS 79 + UDP derivative + trichothecene
    
  • 5xvm - yGT 51 – yeast
    
  • 5gl5 - yGT 51 + UDP-glucose
    
  • 5v2j, 5v2k, 5u6s – AtGT + UDP + laminaribiose + Br-benzoate
    
  • 5u6n, 5u6m – AtGT + UDP + laminaribiose + salicilate
    
  • 6o86, 6o87 – SrGT + UDP – Stevia rebaudiana
    
  • 6o88 – SrGT + UDP + revaudioside
    
• C-GT
  • 6jtd – GT + UDP – Trollius chinensis
    
• Flavonoid GT
  • 3hbf – MtGT + UDP + myricetin – Medicago truncatula
  • 3hbj - MtGT + UDP
  • 2pq6 - MtGT
  • 2c1x, 2c1z – GT + UDP – Vitis vinifera
• Peptidoglycan GT
  • 4jbf, 4ovd – ApGT – Atopobium parvulum
    
  • 4mnr – GT D,D transpeptidase domain – Eggerthella lenta
    
  • 4n1x, 4qjg, 4r1g, 4r23, 4r3j, 4ra7 – ApGT penicillin-binding domain + penicillin
    
  • 4qjg, 4r0q – ApGT penicillin-binding domain + antibiotic
    
  • 5uy7 – GT – Burkholderia ambifaria
    
  • 6bar – TtGT RODA – Thermus thermophilus
    
  • 6bas – TtGT RODA (mutant)
    
  • 3hzs, 3vmq, 5zzk – SaGT - Staphylococcus aureus
    
  • 6ftb – SaGT + moenomycin
    
• Various GT
  • 2iuy, 2iv3 – SvGT – Stretptomyces viridochromogenes
  • 2jjm - BaGT – Bacillus anthracis
    
  • 3oy2 – PcvGT – Paramecium chiorela virus
    
  • 3pnn – GT – Porphyromonas gingivalis
  • 2q3e, 3q3i, 3q3e – ApGT – Actinobacillus pleuropneumomiae
  • 1iir – AoUDP-GT – Amycolatopsis orientalis
  • 3h4i, 3h4t – GT chimera
  • 1cwy – GT – Thermus aquaticus
  • 2iv7, 2iw1, 4rap – EcGT - Escherichia coli
    
  • 4xyw – EcGT (mutant)
    
  • 2xci – AaGT – Aquifex aeolicus
  • 3ia7 – MeGT Calg4 – Micromonospora echinospora
  • 3otk – GT catalytic domain - mouse
    
  • 4ayl - BoGT – Bacterioides ovatus
    
  • 4an4, 4amb, 4amg – GT Snogd – Streptomyces nogalater
    
  • 3wad – ShGT – Streptomyces halstedii
    
  • 4pqg – GT- Streptococcus pneumoniae
    
  • 5du2 - GT – Actinomadura verrucosospora
    
  • 5a01 – DmO-GT catalytic domain (mutant) – Drosophila melanogaster
    
  • 6p61 – GT – Leptospira borgpetersenii
    
• Various GT complexes
  • 1nzd – T4β-GT + UDP-glucose – Phage T4
  • 2nzf, 1nzf - T4β-GT (mutant) + UDP-glucose
    
  • 3vmr, 3vms, 3vmt – SaGT + lipid II analog
    
  • 3mbo – BaGT + UDP + malate
    
  • 3oy7 – PcvGT + GDP-mannose
    
  • 3q3h – ApGT + UDP-Glc
    
  • 1pn3, 1pnv, 1rrv – AoGT + TDP + vancomycin
    
  • 4rb4 – EcGT (mutant) + ADP-heptose
    
  • 2yjn – GT + Dtpd-4-keto-6-deoxy-hexose isomerase – Saccharopolyspora erythraea
    
  • 2xcu – AaGT + CMP
    
  • 3iaa – MeGT Calg2 + TDP
  • 3rsc - MeGT Calg2 + TDP + calicheamicin
    
  • 4ayj – BoGT + glucose + galactose + fucose
    
  • 4cj8, 4cjc - BoGT (mutant) + UDP + galactosamine + UDP-galactosamine
    
  • 4cjb - BoGT (mutant) + GalNac
    
  • 1g9r - GT (mutant) + UDP-galactose + Mn – Neisseria meningitides
    
  • 3wag – ShGT + DTDP
    
  • 5ekp - SyGT + UDP – Synechosystis
    
  • 5eke - SyGT (mutant) + UDP
    
  • 5e9u, 5e9t - GT + UDP + GlcNac + GT chaperone – Streptococcus gordonii
    
  • 6ejj - CjGT + nerylneryl pyrophosphate + UDP - Campylobacter jejuni
    
  • 6eji - CjGT + UDP-galactosamine
    
  • 6ejk - CjGT + nerylneryl pyrophosphate + UDP-galactosamine
    
  • 5v4a - GT + UDP – Streptococcus sanguinis
    
• β-1,4-galactosyltransferase 1 (BGT)

• • 6fwu, 6fwt - hBGT 1 catalytic domain
    
  • 2fy7 - hBGT 1 catalytic domain (mutant)
    
  • 1fgx - bBGT 1 catalytic domain – bovine
    
  • 1pzt, 4krv - bBGT 1 catalytic domain (mutant)
    
  • 3lw6 - DmBGT 7 catalytic domain (mutant)

• BGT 1 binary complexes

• • 1oqm - bBGT catalytic domain + UDP-N-acetylgalactosamine
    
  • 2fya - hBGT 1 catalytic domain (mutant) + Mn
    
  • 4ee3, 4ee4, 4ee5, 4eea, 4eeg, 4eem, 4eeo - hBGT 1 catalytic domain (mutant) + polysaccharide
    
  • 1fr8, 1o0r - bBGT 1 catalytic domain + UDP-galactose
    
  • 1tw5 - bBGT catalytic domain (mutant) + chitobiose
    
  • 1nf5 - bBGT + α-lactalbumin
    
  • 4l41 - bBGT 1 (mutant) + α-lactalbumin
    
  • 1o23 - bBGT catalytic domain + UDP-glucose
    
  • 1oqm - bBGT catalytic domain + UDP-N-acetylgalactosamine
    

• BGT 1 ternary complexes

• • 2fyb - hBGT 1 catalytic domain (mutant) + Mn + UDP
    
  • 2ae7- hBGT 1 catalytic domain + UDP + pentasaccharide
    
  • 2aec, 2aes, 2agd - hBGT 1 catalytic domain + UDP + GlcNAc + mannose
    
  • 2fyc - hBGT 1 catalytic domain (mutant) + UDP-galactose + Ca + α-lactalbumin
    
  • 3ee5 - hBGT 1 catalytic domain (mutant) + UDP + GlcNAc-β1,3-gal-β-naphthalenemethanol
    
  • 2fyd - hBGT 1 catalytic domain + UDP-GlcNAc + Mn + α-lactalbumin
    (mutant) + glucose
    
  • 2ah9 - hBGT 1 catalytic domain + UDP + chitotriose
    
  • 1nhe, 1nkh - bBGT 1 catalytic domain + UDP + α-lactalbumin
    
  • 1yro - bBGT 1 catalytic domain (mutant) + UDP-galactose + α-lactalbumin
    
  • 1nwg - bBGT catalytic domain + N-butanoyl-glucoamine + α-lactalbumin
    
  • 1nmm, 1nqi, 1pzy, 1o7q - bBGT 1 catalytic domain + UDP + GlcNAc
    
• β-1,4-galactosyltransferase 7 (BGT)

• • 1tvy, 1tw1, 4lw3 - bBGT 7 catalytic domain (mutant) + UDP-galactose
    
  • 4irq, 4irp - bBGT 7 catalytic domain + UDP
    
  • 4lw6 - bBGT 7 catalytic domain + xylobiose
    
  • 4m4k - bBGT 7 catalytic domain (mutant) + UDP-galactose + xylobiose
    
  • 3lw6 - DmBGT 7 catalytic domain (mutant)
    

• α-1,3-galactosyltransferase (AGT)

• • 1vzu, 1vzx, 2i7b - hAGT catalytic domain (mutant)
    
  • 2i7b - hAGT catalytic domain (mutant)
    
  • 1g8o, 1fg5, 2jco - bAGT catalytic domain
    
  • 2jcl – bAGT catalytic domain (mutant)
    

• AGT binary complexes

• • 1ziz, 1zjp - hAGT catalytic domain + galactose
    
  • 1zj0 - hAGT catalytic domain + lactose
    
  • 1zj1 - hAGT catalytic domain + N-acetyl lactosamine
    
  • 1zj2, 1zj3 - hAGT catalytic domain + trisaccharide
    
  • 2a8u, 2a8w - hAGT catalytic domain + methyl lactoside
    
  • 1g93, 1gx0 - bAGT catalytic domain + UDP-galactose
    
  • 1k4v - bAGT catalytic domain + UDP
    
  • 2rj0 - bAGT catalytic domain + UDP + Mn
    
  • 1vzt, 2jcj - bAGT catalytic domain (mutant) + UDP
    
  • 2vfz - bAGT catalytic domain (mutant) + UDP-2F-galactose
    
  • 2vs4, 2vs5, 2vxl, 2vxm, 2vs3 - bAGT catalytic domain (mutant) + UDP-galactose
    
  • 2vs3 - bAGT catalytic domain + UDP-galactose
    

• AGT ternary complexes

• • 1r7u, 1r7x - hAGT catalytic domain + inhibitor + fucose
    
  • 1r80 - hAGT catalytic domain + UDP + inhibitor + fucose
    
  • 1r82 - hAGT catalytic domain + UDP-galactose + inhibitor + fucose
    
  • 1gwv - bAGT catalytic domain + UDP + lactose
    
  • 2jck - bAGT catalytic domain (mutant) + UDP + Mn
    
  • 2wgz - bAGT catalytic domain + UDP + nitrophenyl-β-galactoside
    
  • 1o7o - bAGT catalytic domain (mutant) + UDP + lactose
    
  • 1gx4 - bAGT catalytic domain + UDP + N-acetyl lactosamine
    
  • 1gww - bAGT catalytic domain + UDP + glucose
    

• Fucosylglycoprotein 3-AGT (GTB) or histo-blood group ABO system transferase

• • 2rit, 4kxo – hGTB
    
  • 2pgv, 2pgy, 2riz, 2rj5, 1wsz, 2o1f, 2o1g, 5cql, 5cqm, 5cqn, 5cqo, 5cqp, 5cmf, 5cmg, 5cmh, 5cmi, 5cmj, 3ioh, 6bjm, 6bjl, 6bjk, 6bjj, 6bji, 6gwz, 6gwy, 6gx2, 6gx1, 6gx0 – hGTB (mutant)
    
  • 2rix – hGTB + UDP
    
  • 3ioj, 2olh, 5m7b, 5m7c, 5m7d – hGTB (mutant) + UDP
    
  • 4gbp, 4frq, 4fqw, 4fre, 4frh, 4frl, 4frm, 4fro, 4frp, 3sxa, 3sxb – hGTB + UDP-galactose
    
  • 4fra, 4frb, 4frd, 3zgf, 3zgg, 3v0l, 3v0m, 3v0n, 3v0o, 3ioi – hGTB (mutant) + UDP-galactose
    
  • 5m79, 5m7a – hGTB (mutant) + UMP
    
  • 4y62, 4y63, 4y64 - hGTB + amino acid analog
    
  • 3u0x – hGTB + inhibitor
    
  • 3u0y – hGTB (mutant) + UDP + inhibitor
    
  • 2riy – hGTB + H-antigen acceptor
    
  • 1zi4, 1zi5 - hGTB + H-antigen
    
  • 3i0j – hGTB Abo (mutant) + H-antigen
    
  • 2rj1, 2rj6 - hGTB (mutant) + UDP + H-antigen disaccharide
    
  • 2rj8 - hGTB + UDP + H-antigen disaccharide
    
  • 5tjk, 5tjl, 5tjn, 5tjo - hGTB  + UDP + H-antigen trisaccharide
    
  • 5c49 - hGTB (mutant) + UDP-galactose + H-antigen
    
  • 2rj4 - hGTB (mutant) + UDP + ADA
    
  • 5bxc - hGTB + UDP + deoxy-acceptor
    
  • 5c1g, 5c1h, 4c2s - hGTB (mutant) + UDP + deoxy-acceptor
    
  • 2rj9, 5c36, 5c1l - hGTB + UDP-galactose + deoxy-acceptor
    
  • 2rj7, 5c47, 5c48, 5c38, 5c3a, 5c3b, 5c3d, 3v0p, 3v0q - hGTB (mutant) + UDP-galactose + deoxy-acceptor
    
  • 5c8r, 5c4b - hGTB + UDP-glucose + deoxy-acceptor
    
  • 5c4c, 5c4d, 5c4e, 5c4f - hGTB (mutant) + UDP-glucose + deoxy-acceptor
    
  • 3sx3, 3sx5, 3sx7, 3sx8, 3sxc, 3sxd, 3sxe, 3sxg, 1zhj, 1zjo - hGTB catalytic domain + galactose
    
  • 1zi1 - hGTB catalytic domain + lactose
    
  • 1zi3 - hGTB catalytic domain + acetylactosamine

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Michal Harel, Openfox