Neurophysin

spinqualitylabelsall models Neurophysin-2 (green and cyan) complex with oxytocin (magenta and salmon) (PDB code 1npo) Show:Asymmetric Unit Biological Assembly Drag the structure with the mouse to rotate   Export Animated Image   Print3D Function Neurophysins are carrier proteins which transport hormones from the hypothalamus to the posterior pituitary gland. Neurophysin-1 transports oxytocin. Neurophysin-2 transports vasopressin. Oxytocin is used to start labor and increase its speed. Vasopressin functions to retain water in the body and to constrict blood vessels. Disease Mutations in neurophysin-2 are associated with familial diabetes. Structural highlights Neurophysin-2/oxytocin interactions.

3D Structures of neurophysin

Updated on 23-July-2019

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• Neurophysin-1
  • 2lbh, 2lbn – bNP1 – bovine - NMR
    
  • 1l5c, 1l5d – bNP1 (mutant) - NMR
    
  • 2hnw – bNP1 (mutant)
    
  • 2hnu, 2hnv – bNP1 (mutant) + dipeptide
    
• Neurophysin-2
  • 1jk6 – bNP2
    
  • 1npo – bNP2 + oxytocin
    
  • 1jk4 – bNP2 + Lys vasopressin
    
  • 2bn2 – bNP2 + dipeptide
    

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