Histone acetyltransferase 3D structures

3D Structures of histone acetyltransferase

Updated on 28-July-2019

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• Histone acetyltransferase; Human domains – HAT 170-458; catalytic 497-662; bromodomain 729-837;
  • 1f68 – hHAT bromodomain (mutant) – human – NMR
  • 1n72 - hHAT bromodomain – NMR
  • 3d7c - hHAT bromodomain
  • 3gg3 - hHAT PCAF bromodomain
  • 2ou2 - hHAT HTATIP
    
  • 2eko – hHAT HTATIP histone tail-binding domain - NMR
  • 1z4r – hHAT catalytic domain
    
  • 3toa - hHAT Myst1 HAT domain
    
  • 3tob - hHAT Myst1 HAT domain (mutant)
    
  • 2rc4 – hHAT Myst3 acetyltransferase domain
    
  • 5trm - hHAT KAT2A catalytic domain
    
  • 4nsq - hHAT KAT2B
    
  • 4qqg - hHAT KAT5 N terminal
    
  • 2ln0 - hHAT KAT6A
    
  • 4ljn - hHAT KAT6A double PHD finger
    
  • 5wci - hHAT KAT8 HAT domain
    
  • 5j8c, 5j8f - hHAT KAT8 HAT domain (mutant)
    
  • 1qso - yHAT HPA2 – yeast
    
  • 3to7 – yHAT Esa1
    
  • 2rnz – yHAT Esa1 chromodomain – NMR
  • 2ro0 - yHAT Esa1 knotted Tudor domain – NMR
    
  • 1ygh – yHAT HAT domain
    
  • 2qec – HAT HPA2 (mutant) – Corynebacterium glutamicum
    
  • 6ia8, 6iad, 6iaz - HAT – Methanocaldococcus infernus
    
• Histone acetyltransferase binary complexes
  • 1wug, 1wum – hHAT PCAF + small ligand
  • 1zs5 – hHAT bromodomain + inhibitor – NMR
  • 2ozu - hHAT MYST3 catalytic domain + acetyl-CoA
  • 2p0w - hHAT 1 catalytic domain + histone H4 peptide
  • 2rnw, 2rnx - hHAT PCAF bromodomain + histone H3 peptide - NMR
    
  • 5h84 - hHAT KAT2A catalytic domain + propionyl CoA
    
  • 5h86 - hHAT KAT2A catalytic domain + butyryl CoA
    
  • 5trl - hHAT KAT2A catalytic domain + succinyl CoA
    
  • 5mlj, 6j3p - hHAT KAT2A bromodomain + inhibitor
    
  • 5lvq, 5lvr, 5fdz, 5fe0, 5fe1, 5fe2, 5fe3, 5fe4, 5fe5, 5fe6, 5fe7, 5fe8, 5fe9, 5mkx - hHAT KAT2B bromodomain + inhibitor
    
  • 4dnc – hHAT KAT8 HAT domain + male-specific lethal 1 homolog
    
  • 3v43, 4lk9, 4lka, 4llb, 5b75, 5b76, 5b77, 5b78 - hHAT KAT6A + H3.1 peptide
    
  • 5u2j - hHAT KAT6B + H3K14BU peptide
    
  • 5gk9 - hHAT KAT7 + BRD1
    
  • 5ml0 - HAT KAT2B bromodomain + inhibitor - mouse
    
  • 1bob – yHAT 1 + acetyl-CoA
  • 1qsm – yHAT HPA2 + acetyl-CoA
  • 1fy7, 1mja - yHAT Esa1 + CoA
    
  • 3to6 - yHAT Esa1 + H4 peptide
    
  • 4psw - yHAT B + H4 peptide
    
  • 1e6i - yHAT bromodomain + H4 peptide
    
  • 1mj9, 3to9 - yHAT Esa1 (mutant) + CoA
  • 1mjb - yHAT Esa1 (mutant) + acetyl-CoA
  • 3qm0 - yHAT RTT109 (mutant) + acetyl-CoA
  • 3q35, 3q66, 3q68 – yHAT RTT109 + vacuolar protein sorting-associated protein 75
  • 5gcn – TtHAT Gcn5 + CoA – Tetrahymena thermophila - NMR
    
  • 5tpx - HAT GCN5 + probe – Plasmodium falciparum
    
• Histone acetyltransferase ternary complexes
  • 3q33 – yHAT RTT109 + vacuolar protein sorting-associated protein 75 + histone H3 peptide
    
  • 4psx - yHAT B + H3 peptide + H4 peptide
    
  • 5j9q, 5j9t, 5j9u, 5j9w - yHAT Esa1 (mutant) + chromatin modification-related protein + enhancer of polycomb-like protein
    
  • 6cw3, 6cw2 - yHAT GCN5 residues 67-316 + transcriptional adaptor + antibody
    
  • 1q2c - TtHAT Gcn5 + CoA + histone H4 peptide
  • 1q2d - TtHAT Gcn5 + CoA + p53 peptide
• Histone acetyltransferase P300; domains – core domain residues 1043-1519; bromodomain residues 1040-1161; acetyltransferase domain residues 1287-1664; TAZ2 domain 1723-1836:
  • 3i3j – hHAT P300 bromodomain
    
  • 3io2 – hHAT P300 TAZ2 domain
    
  • 4bhw - hHAT P300 core (mutant)
    
  • 6k4n - hHAT P300 bromodomain+acetyltransferase domains – Cryo EM
    
  • 2mh0 - hHAT P300 TAZ2 + transcription factor ITF-1
    
  • 2mh0, 2k8f - hHAT P300 TAZ2 (mutant) + p53 peptide
    
  • 4pzr, 4pzs - hHAT P300 acetyltransferase domain (mutant) + acetyl CoA
    
  • 4pzt - hHAT P300 acetyltransferase domain (mutant) + acetonyl CoA
    
  • 5lkt - hHAT P300 residues 1581-1666 + butyryl CoA
    
  • 5lku - hHAT P300 core + CoA
    
  • 5lkx - hHAT P300 core (mutant) + propionyl CoA
    
  • 5lkz - hHAT P300 core (mutant) + crotonyl CoA
    
  • 3biy – hHAT P300 acetyltransferase domain + lysine CoA derivative
    
  • 5kj2 - hHAT P300 acetyltransferase domain + inhibitor
    
  • 6gyr - hHAT P300 core+acetyltransferase domains + lysine CoA derivative
    
  • 5xzc - hHAT P300 core+acetyltransferase domains + p53
    
  • 5bt3, 5nu5, 5lpk, 5lpm - hHAT P300 bromodomain + inhibitor
    
  • 6gyt - hHAT P300 bromodomain + histone H4 peptide
    
  • 3p57 - hHAT P300 TAZ2 domain + myocyte-specific enhancer factor 2A + DNA

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Michal Harel