6rjv | pdb_00006rjv

The X-ray structure of the Gold/Serum Albumin adduct obtained upon reaction of the protein with AuL12, a gold(III) dithiocarbamate complex

spinqualitylabelsall models 6rjv, resolution 3.21Å Show:Asymmetric Unit Biological Assembly Drag the structure with the mouse to rotate   Export Animated Image   Print3D Structural highlights 6rjv is a 2 chain structure with sequence from Bos taurus. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance. Ligands: AU, MG Resources: FirstGlance, OCA, PDBe, RCSB, PDBsum, ProSAT Function [ALBU_BOVIN] Serum albumin, the main protein of plasma, has a good binding capacity for water, Ca(2+), Na(+), K(+), fatty acids, hormones, bilirubin and drugs. Its main function is the regulation of the colloidal osmotic pressure of blood. Major zinc transporter in plasma, typically binds about 80% of all plasma zinc. Publication Abstract from PubMed The medicinal gold(III) dithiocarbamato complex AuL12 forms a stable adduct with bovine serum albumin. The crystal structure reveals that a single gold(I) center is bound to Cys34, with the dithiocarbamato ligand being released. To the best of our knowledge, this is the first structure for a gold adduct of serum albumin. Structural Characterization of a Gold/Serum Albumin Complex.,Pratesi A, Cirri D, Fregona D, Ferraro G, Giorgio A, Merlino A, Messori L Inorg Chem. 2019 Jul 30. doi: 10.1021/acs.inorgchem.9b01900. PMID:31361466 From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.

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