6jde | pdb_00006jde

crystal structure of a DNA repair protein

spinqualitylabelsall models 6jde, resolution 2.80Å Show:Asymmetric Unit Biological Assembly Drag the structure with the mouse to rotate   Export Animated Image   Print3D Structural highlights 6jde is a 2 chain structure with sequence from Ecoli. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance. Ligands: ZN Gene: radD, yejH, yejI, yejJ, b2184, JW2172 (ECOLI) Activity: DNA helicase, with EC number 3.6.4.12 Resources: FirstGlance, OCA, PDBe, RCSB, PDBsum, ProSAT Function [RADD_ECOLI] May be a helicase. In combination with RadA is important in repair of double-strand DNA breaks (DSB) (PubMed:25425430, PubMed:25484163). Publication Abstract from PubMed The helicase superfamily 2 (SF2) proteins are involved in essentially every step in DNA and RNA metabolism. The radD (yejH) gene, which belongs to SF2, plays an important role in DNA repair. The RadD protein includes all seven conserved SF2 motifs and has shown ATPase activity. Here, we first reported the structure of RadD from Escherichia coli containing two RecA-like domains, a zinc finger motif, and a C-terminal domain. Based on the structure of RadD and other SF2 proteins, we then built a model of the RedD-ATP complex. Crystal structure of a novel ATPase RadD from Escherichia coli.,Kuang X, Tang Q, Liu YP, Yan XX, Xu W Proteins. 2019 Apr 29. doi: 10.1002/prot.25704. PMID:31035307 From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.

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