3D structures of insulin receptor
Updated on 29-August-2019
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- Insulin receptor; domains: L1-CR 28-337; 1-3 28-512; transmembrane 940-988; TK 1005-1310;
- 1irk – hIR TK domain – human
- 1i44, 1p14 – hIR TK domain (mutant)
- 2hr7 – hIR domains 1-3
- 4xst – hIR L1-CR domains
- 2mfr – hIR transmembrane domain - NMR
- Insulin receptor; domains: L1-CR 28-337; 1-3 28-512; transmembrane 940-988; TK 1005-1310;
- 5j3h – hIR L1-CR domains + antibody + peptide
- 4xss – hIR L1-CR domains + insulin-like growth factor 1
- 4xlv - hIR TK domain (mutant) + ATP derivative
- 1ir3 - hIR TK domain (mutant) + ATP analog + peptide
- 3bu5, 3bu6 - hIR TK domain + ATP + peptide
- 3bu3 - hIR TK domain + peptide
- 1gag, 2z8c - hIR TK domain (mutant) + peptide
- 3ekk, 3ekn, 4ibm, 5hhw - hIR TK domain (mutant) + inhibitor
- 3eta, 5e1s - hIR TK domain + inhibitor
- 4zxb - hIR ectodomain (mutant) + antibody
- 2auh – hIR TK domain + growth factor receptor-bound protein 14
- 2b4s - hIR TK domain + tyrosine-protein phosphatase
- 1rqq – hIR TK domain (mutant) + adaptor protein PS
- 6ce7, 6ce9, 6ceb – hIR + insulin [1]
- 6hn4, 6hn5 - hIR + insulin [2]
- 5kqv – hIR + insulin + antibody
- ↑ Scapin G, Dandey VP, Zhang Z, Prosise W, Hruza A, Kelly T, Mayhood T, Strickland C, Potter CS, Carragher B. Structure of the Insulin Receptor-Insulin Complex by Single Particle CryoEM analysis. Nature. 2018 Feb 28. pii: nature26153. doi: 10.1038/nature26153. PMID:29512653 doi:https://dx.doi.org/10.1038/nature26153
- ↑ Weis F, Menting JG, Margetts MB, Chan SJ, Xu Y, Tennagels N, Wohlfart P, Langer T, Muller CW, Dreyer MK, Lawrence MC. The signalling conformation of the insulin receptor ectodomain. Nat Commun. 2018 Oct 24;9(1):4420. doi: 10.1038/s41467-018-06826-6. PMID:30356040 doi:https://dx.doi.org/10.1038/s41467-018-06826-6
